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In an attempt to differentiate acute HBV infection from persistent HBs-Ag carrier state serologically on single serum sample, IgM class and IgG class antibodies to hepatitis B core antigen were tested.<BR>IgM anti-HBc titer was significantly higher in acute hepatitis B (42 cases) than in chronic HBs-Ag carriers (183 cases). The titer of this class antibody, however, was relatively low in 2 cases with acute hepatitis B and moderately high in 15 cases with HBs-Ag positive chronic liver diseases, leading to the difficulty in making a differentiation between two categories of HBV infection by the assay of IgM class anti-HBc alone.<BR>Hence, the ratio of IgM class anti-HBc to IgG class anti-HBc was calculated. This ratio was over 0.9 in 41 of 42 cases with acute hepatitis B and below 0.9 in 180 of 183 cases with chronic HBs-Ag carriers. Thus, the determination of this ratio was found to be of great value in separating acute HBV infection from chronic HBs-Ag carrier state.
社団法人日本肝臓学会の論文