肝癌発生の臨床病理学的研究--肝炎・肝硬変からの追跡例44例を中心に

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Clinical and pathohistological studies on the 44 cases with hepatitis or cirrhosis of the liver histologically confirmed by biopsy except 5 cases, who developed hepatoma in variable periods of time of follow-up, were reported.<BR>The prevalence of HBsAg in their sera was 35.7% and that of anti-HBc was 67.4%. All cases whose sera were positive for HBsAg at death showed positive HBsAg in the liver obtained by biopsy on the first occasion. This indicated that they had persistent infection of HBV.<BR>Retrospective studies suggested that HBsAg positive, latent cirrhosis appeared to have a higher risk to develop hepatoma. Frequent determination of serum AFP could not be a clue for the early detection of the hepatoma so far in cases reported. In the biopsied liver of a case with chronic active hepatitis was found a minimal deviation hepatoma 4 years befbre the full-development of hepatoma. This finding suggested that hepatoma with cirrhosis might develop in some cases already in a stage of chronic hepatitis.
社団法人日本肝臓学会の論文