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We made an attempt at quantative measurement of hepatitis B e antigen (HBeAg) by enzyme immunoassay (EIA). Its measurable range was from one to 100 units. (This is tentatively established unit.) In the specimen contained high concentration of HBeAg over 100 units, its concentration is determined after appropriate dilution. At reproducibility test, the coefficient of variation in intra- and inter-assays were 4.24-11.82%, 8.57-13.39%, respectively and the mean recovery was 98.45% (range 82.6% to 109.1%). In respect of the relationship between concentration and cutoff index of HBeAg in EIA method, they were correlated with together in the low concentration range, but its relationship dissociated when cutoff index exceeded 2.5. Concentration of HBeAg were not correlated with hepatitis B virus (HBV)-associated DNA polymerase activities and hepatitis B surface antigen (HBsAg) titers in the cases of HBsAgpositive chronic hepatitis. This assay system is very useful to put forward the clinical approach to HBV infection.
社団法人日本肝臓学会の論文