免疫グロブリン製剤によるA型肝炎の感染予防に関する研究

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The authors have carried out the retrospective study on the actual condition of hepatitis A virus (HAV)infection in a group of Japanese residents in Algeria in an attempt to evaluate the prophylactic effect of human immune serum globulin (I.S.G.) on HAV infection. The I.S.G. preparation used for this study had titers of 1: 400 and 1: 800 by RIA, which was intramuscularly injected in a dose of 4 mg per Kg of body weight for a total of 3 times at two-month intervals. <BR>During a period of 6 months, 4 out of 40 subjects not given I.S.G. were to have been infected with HAV, and of these, two were asymptomatic in their infection and the other two had clinically developed acute hepatitis. However, no acute hepatitis was recognized in a group of 53 subjects given I.S.G., although in one of these subjects, asymptomatic infection was noted. When the crude attack ratios between these two groups were compared, the fbrmer was significantly higher with 10.0%than the latter with l.9%. The efFicacy of I.S.G. in preventing HAV infection was found to be 81%. From these results, it was confirmed that the possible evelopment of hepatitis A could be prevented when I.S.G. be administered. <BR>Twenty-seven lots of I.S.G. put on the market in Japan over the years 1977-1980 possessed HAV antibody, ranging in titer from 1: 100 to 1: 800 with a geometric mean titer of 1: 270 by RIA. Al1 lots appeared to contain considerable amounts of HAV antibody, suggesting the possibility that such I.S.G. would be effective in preventing hepatitis A.
社団法人日本肝臓学会の論文

免疫グロブリン製剤によるA型肝炎の感染予防に関する研究

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