Effects of H5-DTPA and Ca-DTPA on the removal of 59Fe from rats injected with 59Fe-iron dextran.
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Rats injected intravenously with the 59Fe-iron dextran were treated with two chelating agents, H5-DTPA and Ca-DTPA. The removal effects were compared between H5-DTPA and Ca-DTPA to estimate the usefulness of H5-DTPA for the chelating treatment in the accidental contamination with radioactive metal elements.H5-DTPA was administered by subcutaneous implantation and Ca-DTPA by intraperitoneal injection 30 min or 24h after the injection of 59Fe-iron dextran. The tissue distribution of 59Fe was not largely different between the treatments with two chelating agents. The excretion of 59Fe into the feces was increased with both H5- and Ca-DTPA to about 7 times that of control. With respect to the fecal excretion, the effect of H5-DTPA was the same level as that of Ca-DTPA treated group. On the other hand, the urinary excretion was strongly increased by the H5-DTPA treatment and the effect was 3.4 times that of Ca-DTPA treated rats.
- 日本保健物理学会の論文
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