The deposition pattern of insoluble particles with different sizes in the rat trachea.

概要

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In order to clarify the relation between the size of particles and their retention sites in the tracheal wall, Wistar rats were intratracheally administered four kinds of tracer particles, i. e., colloidal carbon of 0.03μm, colloidal gold of 0.01μm, and fluorescent latex particles of 0.27 and 1.24μm in diameter. The distribution of the tracer particles in the distal trachea was examined by light microscopy 3h and 3 days after instillation. The uptake of particulates by the epithelial cells of the trachea seemed to be rare events, especially for latex particles of both sizes. Only for colloidal carbon and colloidal gold, a slight uptake by the epithelial cells was observed 3 days after instillation. On the other hand, all the four kinds of tracer particles were buried in the tracheal wall 3 days after instillation. The latex particles were mainly situated in or beneath the basement membrane of the epithelial cells. The distribution of colloidal carbon and colloidal gold seemed to be a little broader than that of the latex particles but otherwise similar to it.
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