Distribution of ^<198>Au and ^<133>Ba in Thoracic and Cervical Lymph Nodes of the Rat following the Intratracheal Instillation of ^<198>Au-colloid and ^<133>BaSO_4

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In this study, the transportability of ultrafine particles from the lung to the regional lymph nodes was investigated. ^<198>Au-colloid particles with 0.02 μm count median diameter (CMD) and ^<133>BaSO_4 particles with 0.39 μm CMD were instilled into rat lungs via intratracheal cannulas. Both the ^<198>Au-colloid and the ^<133>BaSO_4 were distributed mainly to the posterior mediastinal lymph nodes. There were no significant differences between the quantities of the ^<198>Au-colloid and ^<133>BaSO_4 particles which reached the regional lymph nodes. This suggests that the mode of transporting ultrafine particles such as ^<198>Au-colloid from the lung to regional lymph nodes is similar to that of particles in the micrometer size range.
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