Transfer of ^<239>Pu to mouse fetoplacental tissues

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Cross-placental transfer of ^<239>Pu from the mother to fetus was studied in C3H mice. The activity of ^<239>Pu in the conceptus was measured 24 hrs after the intravenous injection of ^<239>Pu citrate on days 10.5 to 16.5 of gestation. More ^<239>Pu was transferred to the conceptus when the plutonium was administered in the later stages of gestation; 0.12% of the injected dose per conceptus on day 10.5 and 1.3% on day 16.5. In all the gestational stages examined, the yolk sac and decidua contained more than 89% of the total activity distributed in the conceptus. The concentration of ^<239>Pu in the yolk sac was about two orders of magnitude greater than that in the fetus. The ^<239>Pu concentration in the maternal liver decreased with the gestational stage. In the early gestational stages the concentration in the maternal liver was greater than that in the yolk sac; but, this relationship was reversed in the later stages. The embryo and fetus are considered to be more sensitive than the adult to ionizing radiation with regard to many biological aspects including cancer induction1).
日本放射線影響学会の論文