The Effects of Polymeric Plutonium on Erythrocvte Survival in Mice (I)

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The changes in erythrocyte counts, hematocrit, hemoglobin, reticulocyte counts and erythrocyte survival following an intravenous injection of polymeric ^<239>Pu at the does level of 15 μCi/kg, 10 μCi/kg and 5 μCi/kg were studied in CF#1 male mice in order to investigate the possible pathogenesis of anemia produced by irradiation of polymeric plutonium. The administration of 15 μCi/kg and 10 μCi/kg of polymeric plutonium produced anemia but 5 μCi/kg had no significant effect. Studies with ^<51>Cr labelled erythrocyte showed a moderate reduction in survival of erythrocyte following a single intravenous injection of polymeric plutonium. Not only the intracorpuscular effect but also extracorpuscular effect of polymeric plutonium was considered to lead to a reduction in erythrocyte survival, but no clear dose relationship could be observed between the reduction of survival and either intracorpuscular effect or extracorpuscular effect. Although the most important pathogenesis of anemia produced by polymeric plutonium is supposed to be a decreased erythropoiesis, it was believed that both qualitatively impaired erythropoiesis and abnormal erythrocyte destruction might also play some role in the occurrence of anemia.
日本放射線影響学会の論文