Changes in 59Fe Uptake into Erythrocytes and Chemically Separated Heme Fractions of Spleen and Femoral Bone Marrow after Irradiation with X-rays at Different Doses in OK-432 Treated Mice.

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The radiation dose range in which OK-432 would promote the recovery of radiation-impaired erythropoiesis was investigated. C57BL/6J male mice were injected with a single dose of 5 KE of OK-432 1h before or 1h after irradiation with X-rays. Erythropoietic activity was measured by 59Fe incorporation into circulating erythrocytes and the chemically separated heme iron fraction of erythropoietic tissues.When irradiated with 94.5cGy to 567cGy of X-rays the uptake of 59Fe into circulating erythrocytes was promoted within 20 days after irradiation by the treatment with OK-432. Treatment with OK-432 1h before otherwise lethal irradiation with 662cGy significantly enhanced the 59Fe uptake into erythrocytes. These results demonstrate that OK-432 stimulates erythropoietic recovery in sub-lethally and lethally irradiated mice.At long time intervals following irradiation with 567cGy or 662cGy of X-rays, the 59Fe uptake into erythrocytes in the OK-432-treated group was quite similar to the corresponding non-irradiated controls. Further studies to ascertain whether OK-432 can be used as a radioprotective agent are currently in progress.
日本保健物理学会の論文