Diminished Osmotic Fragility of Mouse Erythrocytes Following Intravenous Injection of Polymeric Plutonium

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Changes in the osmotic fragility and the mean corpuscular diameter of erythrocytes in CF#1/Nrs male mice caused by internal irradiation with polymeric ^<239>Pu at the dose levels of 15 pCi/kg, 10 pCi/kg and 5 μCi/kg were studied at 28 and 56 days after intravenous injection of plutonium. At 56 days after injection of plutonium, osmotic fragility curves were found to shift toward lower NaCl concentration in proportion to the amount of plutonium injected, which indicated the reduction of osmotic fragility. The size distribution curves of erythrocytes were slightly shifted toward larger size, depending on the amount of plutonium injected. Mean corpuscular diameter of erythrocytes in the highest dose group was significantly larger than that of control group. Mean corpuscular thickness of erythrocytes in plutonium injected groups was not different from that of control group. The increase in the mean corpuscular diameter-to-thickness ratio might allow the erythrocyte to accumulate a larger volume of water in a hypotonic environment before reaching the critical hemolytic volume.
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