Effect of Internal Exposure by 90Sr and 131I on Respiratory 14CO2 Patterns following 14C-Glucose Administration in Mice

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Effects of internal irradiation by ^<90>Sr and ^<131>I were compared using ^<14>C-glucose oxidation test in mice. Mice were injected with 2 μCi/g body weight of ^<90>Sr or 5 μCi/capita of ^<131>I for internal irradiation. At one day or 1, 3, 6, 9 weeks after injection of ^<90>Sr and one or seven days after injection of ^<131>I, the respiratory ^<14>CO_2 patterns of the animals were studied by continuous measurement of ^<14>CO_2 and CO_2 in the exhaled air. The time course pattern of specific activity was obtained by calculating the ratios of the observed value of ^<14>CO_2 and CO_2. The effect of internal exposure on respiratory ^<14>CO_2 were evaluated by the following parameters; 1) peak time,i.e., the time from injection to maximum specific activity, and 2) peak height, the maximum specific activity at peak time. In the control group, the value of specific activity of exhaled ^<14>CO_2 increased immediately after ^<14>C-glucose administration, reached the maximum at 30 minutes and then gradually decreased. Internal irradiation with ^<90>Sr caused a front shift,i.e., decrease in peak time with no appreciable change in peak height as compared with control. In the case of ^<131>I, the respiratory pattern underwent an upper shift,i,e., increase in peak height with no change in peak time. To clarify the mechanism of the phenomena obtained by these internal emitters, the effect of some drugs on the change of respiratory ^<14>CO_2 pattern were studied. It was suggested that respiratory ^<14>CO_2 pattern analysis may serve as a useful tool in the comparative study of the effect of various internal emitters.
日本放射線影響学会の論文

Effect of Internal Exposure by 90Sr and 131I on Respiratory 14CO2 Patterns following 14C-Glucose Administration in Mice

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