静脈注射用コンドロイチン硫酸鉄コロイドについて(第3報) : ^<59>Fe標識コンドロイチン硫酸鉄コロイドのマウス投与後における^<59>Feの体内分布その1

概要

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Body distribution of iron [^<59>Fe] chondroitinsulfate was examined by intravenous injection of its colloid in mice, either by radioactivity counting after autopsy or by a whole-body autoradiography. 1) The labelled iron chondroitinsulfate after intravenous injection is phagocytized by the reticuloendothelial system cells, mainly the liver, and iron is transported to hemopoietic organs such as the spleen and bone marrow, and then further transits to erythrocytes. 2) Changes in the dose administered results in the speed of phagocytosis by the liver and uptake into erythrocytes, the greater the speed, the smaller the dose. Naturally, the abosolute amount of iron taken up is greater, the larger the dose. 3) A part of excess iron is excreted through the small intestine into feces but there is hardly any excretion into urine. 4) It was found through whole-body autoradiography that iron transits to villi in the small intestine and also to the skin. 5) Distribution of iron in various organs found by radioactivity counting after autopsy corresponded well with the result of whole-body autoradiography.
社団法人日本薬学会の論文
1969-07-25