Difference between C3H Mice and Wistar Rats in the Effect of External γ-Irradiation on ^<59>Fe Release from Alveolar Macrophage-Ingested ^<59>Fe-Iron Hydroxide Colloid

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The effect of external γ-irradiation on ^<59>Fe release from alveolar macrophages (AMs) that had ingested ^<59>Fe-iron hydroxide colloid was determined in C3H mice and Wistar rats with an in vitro assay system. The release of ^<59>Fe from AM was increased by irradiation in mice but not in rats. A significant increase in ^<59>Fe release was seen in mouse AM cultured for 72 hrs after irradiation at a dose of more than 25 Gy; but, graded doses of γ-irradiation up to 100 Gy had no effect on ^<59>Fe release from rat AMs. This difference between mice and rats may be attributable to the magnitude of death of or damage to AM because the survival of AMs assessed by vital staining with crystal violet decreased much more in mice than in rats.
日本放射線影響学会の論文