Synthesis of Anti-Tumor Dimeric Indole Alkaloids in Catharanthus roseus Was Promoted by Irradiation with Near-Ultraviolet Light at Low Temperature
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概要
- 論文の詳細を見る
We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.
- 社団法人 日本農芸化学会の論文
著者
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Yoshikawa Tomoaki
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka Unive
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Bamba Takeshi
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Harada Kazuo
Department Of Biotechnology Graduate School Of Engineering Osaka University:(present Office)departme
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Hirata Kazumasa
Applied Environmental Biology Graduate School Of Pharmaceutical Sciences Osaka University
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Hirata Kazumasa
Department of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences, Osaka Unive
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Asano Mamiko
Department of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences, Osaka Unive
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