Bioactivities of Nostocine A Produced by a Freshwater Cyanobacterium Nostoc spongiaeforme TISTR 8169
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概要
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A freshwater cyanobacterium, Nostoc spongiaefortne TISTR 8169, synthesizes and releases a violet pigment, nostocine A, into medium. We examined the bioactivity of nostocine A to several model organisms breeding with N. spongiaeforme in the natural environment. To microalgae, nostocine A exhibited growth inhibitory activity comparable to paraquat, and the activity tended to be stronger to green algae than to cyanobacteria. Nostocine A also exhibited strong inhibitory activity to the root elongation of barnyard grass, strong antifeedant activity to cotton ballworm, and acute toxicity to mice resulting in its classification as a dangerous poison. The results suggest that nostocine A may act as a toxin or an allelochemical to breeding organisms in nature. In a laboratory culture of N, spongiaeforme, the production of nostocine A was enhanced at higher temperature, 30℃, and more intense light, 30 W/m^2, than the basal conditions, 25℃ and 10 W/m^2. Cultivation of cells with H_2O_2 at 1 or 2 mM also enhanced the production of nostocine A, indicating that nostocine A may be synthesized and released when the cells are exposed to oxidative stress, possibly occurring at higher temperature and more intense light. LC-MS and electron spin resonance analyses revealed that nostocine A, reduced previously by NaBH_4, immediately recovered to its original form upon exposure to air and the generation of superoxide radical anions occurred at this re-oxidation step. These results suggest that the adverse effects of nostocine A on various organisms may be related to the function of nostocine A in generating toxic reactive oxygen species, which occurs in the cells of target organisms.
- 社団法人日本生物工学会の論文
- 2003-05-25
著者
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Hirata Kazumasa
Applied Environmental Biology Graduate School Of Pharmaceutical Sciences Osaka University
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MAHAKHANT Aparat
Thailand Institute of Scientific and Technological Research
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Hashimoto K
Environmental Bioengineering Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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HIRATA KAZUMASA
Environmental Bioengineering Laboratory, Graduate School of Pharmaceutical Sciences, Osaka Universit
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MIYAMOTO KAZUHISA
Environmental Bioengineering Laboratory, Graduate School of Pharmaceutical Sciences, Osaka Universit
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Mahakhant Aparat
TISTR culture Collection, Thailand Institute of Scientific and Technological Research
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Hirata Kazumasa
Department Of Biochemical Engineering Faculty Of Pharmaceutical Sciences Osaka University
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Hirata Kazumasa
Environmental Bioengineering Laboratory Graduated School Of Pharmaceutical Sciences Osaka University
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Hirata Kazumasa
Environ. Bioeng. Lab Grad. Sch. Pharm. Sci. Osaka Univ.
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Miyamoto Kazuhisa
Environmental Biotechnology Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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Miyamoto Kazuhisa
Environmental Bioengineering Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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Mahakhant Aparat
Tistr Culture Collection Thailand Institute Of Scientific And Technological Research
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Miyamoto K
Environmental Biotechnology Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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YOSHITOMI SAYAKA
Environmental Biotechnology Laboratory, Graduate School of Pharmaceutical Sciences, Osaka University
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DWI SUSILANGSIH
Environmental Biotechnology Laboratory, Graduate School of Pharmaceutical Sciences, Osaka University
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IWABE OSAMU
Environmental Biotechnology Laboratory, Graduate School of Pharmaceutical Sciences, Osaka University
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POLCHAI JIRAPATCH
Thailand Institute of Scientific and Technological Research
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Iwabe Osamu
Environmental Biotechnology Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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Dwi Susilangsih
Environmental Biotechnology Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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Hirata K
Environmental Biotechnology Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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Hirata Kazumasa
Osaka Municipal Technical Research Institute
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Mahakhant A
Tistr Culture Collection Thailand Institute Of Scientific And Technological Research
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Yoshitomi Sayaka
Environmental Biotechnology Laboratory Graduate School Of Pharmaceutical Sciences Osaka University
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Miyamoto Kazuhisa
Environmental Bioengineering Laboratory Faculty Of Pharmaceutical Sciences Osaka University
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