Microbial Synthesis of Purine Arabinosides and Their Biological Activity

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概要

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• A simple method for the synthesis of various purine arabinosides from purine bases and uracil arabinoside by microbial transarabinosylation is described. A wet cell paste of Enterobacter aerogenes AJ 11125 showed a wide substrate specificity range for purine bases. Not only naturally occurring purine bases such as adenine and hypoxanthine but also unnatural bases such as 6-thioguanine and 2-chlorohypoxanthine were catalyzed to give the corresponding purine arabinosides. The enzymatically synthesized purine arabinosides were isolated from the reaction mixtures and identified by physicochemical means. The biological activities of the compounds were investigated and it was found that thioguanine arabinoside and 2-methyladenine arabinoside have potent activity against Hela cells, and their ED50 were 10.5 and 21.5μg/ml, respectively.

• 社団法人 日本農芸化学会の論文

著者

• Yamanaka Shigeru

  Central Research Laboratories Ajinomoto Co. Inc.

• Yamazaki Akihiro

  Central Research Laboratories Ajionmoto Co. Inc.

• Hirose Yoshio

  Central Research Laboratories Of Ajinomoto Co. Inc.

• Yoshinaga Fumihiro

  Central Research Laboratories Of Ajinomoto Co. Inc.

• YAMAZAKI Akihiro

  Central Research Laboratories of Ajinomoto Co., Inc.

• UTAGAWA Takashi

  Central Research Laboratories of Ajinomoto Co., Inc.

• MORISAWA Hirokazu

  Central Research Laboratories of Ajinomoto Co., Inc.

• HIROSE Yoshio

  Central Research Laboratories of Ajinomoto Co.

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