Microbiological Synthesis of Adenine Arabinoside

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概要

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• The microbiological synthesis of 9-β-D-arabinofuranosyl adenine (ara-A, an antiviral drug) from adenine and arabinofuranosyluracil (ara-U) is described. Various bacteria, especially Enterobacter aerogenes, Escherichia coli, Erwinia herbicola and Aeromonas salmonicida, were found to be able to transfer the arabinofuranosyl moiety of ara-U to adenine (transarabinosylation) in the presence of inorganic phosphate. The optimum conditions for the transarabinosylation were pH 7.0 and 60°C. No reaction was observed in the absence of inorganic phosphate and its optimum concentration was around 30 mM. Six grams of ara-A was produced in liter of reaction mixture in the presence of wet cell paste of Enterobacter aerogenes AJ 11125. Ara-A formed was precipitated in the reaction mixture and isolated with an 87% yield. Physicochemical data for the compound agreed with those of authentic ara-A.

• 社団法人 日本農芸化学会の論文

著者

• MITSUGI Koji

  Central Research Laboratories of Ajinomoto Co., Inc.

• Yamazaki Akihiro

  Central Research Laboratories Ajionmoto Co. Inc.

• Mitsugi Koji

  Central Research Laboratories Ajinomoto Co. Inc.

• Hirose Yoshio

  Central Research Laboratories Of Ajinomoto Co. Inc.

• Yoshinaga Fumihiro

  Central Research Laboratories Of Ajinomoto Co. Inc.

• HIROSE YOSHIO

  Central Research Laboratories of Ajinomoto Co., Inc.

• UTAGAWA Takashi

  Central Research Laboratories of Ajinomoto Co., Inc.

• MORISAWA Hirokazu

  Central Research Laboratories of Ajinomoto Co., Inc.

• HIROSE Yoshio

  Central Research Laboratories of Ajinomoto Co.

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