T1601-2-3 フェンス状ナノ構造配列を用いたDNA分離用マイクロチップの設計理論の構築(マイクロナノダイナミクスの計測と制御・マイクロナノメカトロニクス(2))

概要

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We developed a micro-fabricated chip to separate bio-molecules by their molecular sizes based on the principle of the size exclusion chromatography (SEC). The nano-sized fence array was integrated in our chip for the separation. One of the features of the chip is that the separation property can be controlled by the design offences' size and their arrangement. In this study, we constructed the theoretical model to estimate the separation properties of our chip assuming the motions of the DNA molecules as random walking spheres. Validity of the model was confirmed by comparing the results of theoretical calculation and those of the experiments.
社団法人日本機械学会の論文
2009-09-12