Recent developments in processing systems for cell and tissue cultures toward therapeutic application
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概要
- 論文の詳細を見る
Innovative techniques of cell and tissue processing, based on tissue engineering, have been developed for therapeutic applications. Cell expansion and tissue reconstruction through ex vivo cultures are core processes used to produce engineered tissues with sufficient structural integrity and functionality. In manufacturing, strict management against contamination and human error is compelled due to direct use of un-sterilable products and the laboriousness of culture operations, respectively. Therefore, the development of processing systems for cell and tissue cultures is one of the critical issues for ensuring a stable process and quality of therapeutic products. However, the siting criterion of culture systems to date has not been made clear. This review article classifies some of the known processing systems into 'sealed-chamber' and 'sealed-vessel' culture systems based on the difference in their aseptic spaces, and describes the potential advantages of these systems and current states of culture systems, especially those established by Japanese companies. Moreover, on the basis of the guidelines for isolator systems used in aseptic processing for healthcare products, which are issued by the International Organization for Standardization, the siting criterion of the processing systems for cells and tissue cultures is discussed in perspective of manufacturing therapeutic products in consideration of the regulations according to the Good Manufacturing Practice.
- 社団法人日本生物工学会の論文
著者
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Taya Masahito
Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of En
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Kino-oka Masahiro
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Kino-oka Masahiro
Department Of Biotechnology Graduate School Of Engineering Osaka University
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Taya Masahito
Division Of Chemical Engineering Graduate School Of Engineering Science Osaka University
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Taya Masahito
Division Of Chemical Engineering Department Of Materials Engineering Science Graduate School Of Engi
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