脊髄反射活動電位におよぼすChlorpromazineの作用(<特集>脳と神経の研究)

概要

論文の詳細を見る
The effects of chlorpromazine (CPZ) on the segmental (L_7 or S_1) spinal cord reflex potentials were determined in urethane anesthetized or spinal preparations in both normal cats and the cats exhibiting extensor rigidity of the hind-limbs produced by temporary occlusion of the blood supply to the lumbar spinal cord ("ischemic rigid cat"). CPZ was administered intravenously in all cases. 1) CPZ markedly depressed the monosynaptic reflex potential in urethane anesthetized cats, but, not in spinal or "ischemic rigid" cats. 2) The depressing effect of CPZ in anestnetized cats is independent of the action of anesthetics on the spinal cold, and is not the result following a decrease in the blood pressure. 3) The monosynaptic reflex potential in spinal or " ischemic rigid " cats was transiently and remarkably increased by CPZ. 4) Thus, the depressing effect of CPZ on the spinal cord reflex potentials, is apparently due to the action at the supraspinal level. Furthermore, CPZ may facilitate the activity oif the alpha system in the spinal cord. 5) An analysis of the effects of CPZ shows that the "ischemic spinal cord rigidity" is precisely a result of interneurone destruction in the spinal cord, and is probably, in essence, "alpha rigidity".
千葉大学の論文
1964-09-28