Effects of Naloxone ad Levallorphan on the Spinal Cord Reflex Potentials under the Spinal Ischemic Condition in Cats.
スポンサーリンク
概要
- 論文の詳細を見る
The spinal reflex potentials elicited by electrical stimulation of the tibial nerve were recorded from the lumbo-sacral ventral root in spinal cats. When the thoracic aorta and the bilateral internal mammary arteries were occluded for 10 min, the potentials were completely depressed. Reappearance of these potentials could be observed at about 10 min after removal of the occlusion and they gradually recovered. Intravenous injection of naloxone (1 or 10 mg/kg) or levallorphan (0.1 mg/kg) together with removal of occlusion significantly promoted the recovery of the polysynaptic reflex potential. Morphine (5 mg/kg) showed no particular effect on the recovery of potentials. Furthermore, pretreatment with morphine (5 mg/kg) did not influence the effects of these opioid antagonists. These results suggest that naloxone and levallorphan may preserve or potentiate the interneuronal activities of the lumbo-sacral spinal cord under the ischemic condition and that the effects may not be mediated through morphine-like opioid receptors.
- 公益社団法人 日本薬理学会の論文
著者
-
Okamoto Yuzuru
Department Of Orthopaedic Surgery Graduate School Of Medicine Chiba University
-
Suzuki Toshio
Department Of Agronomy Faculty Of Agriculture Tohoku University
-
MURAYAMA Satoshi
Department of Pharmacology, School of Medicine, Chiba University
-
Murayama Satoshi
Department Of Pharmacology School Of Medicine Chiba University
関連論文
- Androgen Suppresses Corticotropin-Induced Increase in Plasma Cortisol Level but Enhances The Increase in Plasma Aldosterone Level in Goats(Physiology)
- Numerical Simulation of Peritectic Reaction in Fe-C Alloy Using a Multi-phase-field Model
- Phase-field modeling of rapid solidification in small alloy droplets
- Ostwald Ripening Analysis Using Phase-Field Model
- Numerical Prediction of the Secondary Dendrite Arm Spacing Using a Phase-feild Model
- Phase-field Model for Solidification of Ternary Alloys
- Numerical Simulation of the Critical Velocity for Particle Pushing/Engulfment Transition in Fe-C alloys Using a Phase-field Model
- Numerical Simulation of Interface Shape around an Insoluble Particle for Fe-C Alloys Using a Phase-field Model
- Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli
- 23. 植えこみ電極法による脳波測定について(第34回千葉医学会総会講演要旨)
- Identification of cell proliferation-associated epitope on CD98 oncoprotein using phage display random peptide library
- Molecular Structural and Functional Characterization of Tumor Suppressive Anti-ErbB-2 Monoclonal Antibody by Phage Display System
- Phage Display Cloning and Characterization of Monoclonal Antibody Genes and Recombinant Fab Fragment against the CD98 Oncoprotein
- Pyribenzyl methylsulfate(CG-201)の薬理(脳と神経の研究V)
- 11. Chlorpromazineの薬理(第31回千葉医学会,昭和29年度千葉県医師会医学会連合大会演説要旨)
- 2-Hydroxyphenyl-1, 3-dimethylbenzimidazolines. Formal Two Hydrogen Atom-donors for Photoinduced Electron Transfer Reactions
- Recent Advances in the Phase-field Model for Solidification
- はじめに(バイオエシックス)
- いわゆる"Antiphobic Drug" Pipethanateの新誘導体(PI-3610-T)の薬理作用(脳と神経の研究II)
- 20) 上頸交感神経節への薬物の応用(第407回千葉医学会例会 第13回中山外科例会)
- Sarcolemmal ATP-sensitive K^+ channels and cardiovascular function
- Numerical Simulation of Peritectic Reaction Using a Multi-phase-field Model
- Effects of lipo-prostaglandin E_1 on blood flow and oxygen pressure in lumbo-sacral nerve roots
- 4-6. L-DOPAの脊髄作用(昭和45年度(1970)千葉大学医学部公開講座抄録集)
- No Association of the G1287A Polymorphism in the Norepinephrine Transporter Gene and Susceptibility to Major Depressive Disorder in a Japanese Population(Biopharmacy)
- Genetic Polymorphism of C452T (T127I) in Humanγ-Glutamyl Hydrolase in a Japanese Population(Biopharmacy)
- 24. 腹窓法によるGABA誘導体の腸管作用の検討(一般口演,第44回千葉医学会総会 第13回千葉県医師会学術大会 第6回日医医学講座連合大会)
- 4) 血圧下降剤Rauwolfia serpentinaの薬理(千葉医学会第30回総会,昭和28年度千葉県医師会医学会連合大会)
- 29. 二・三抗赤痢・サルモネラ菌剤の薬理(基礎医学,千葉医学会第29回臨時総会演題)
- Immunoliposome-Mediated Gene Transfer into Cultured Myotubes
- Examination of Local Anti-inflammatory Activities of New Steroids, Hemisuccinyl Methyl Glycolates
- Application of Sweet Potato Fiber to Skin Wound in Rat
- Chrono and clinical pharmacokinetic study of tacrolimus in continuous intravenous administration
- Effects of a phenolic compound, resveratrol, on the renal function and costimulatory adhesion molecule CD86 expression in rat kidneys with ischemia/reperfusion injury
- Analysis of Pion Photoproduction on Nucleons below 500 MeV
- The Production Asymmetry in γ+n⇾π^-+p Process with Polarized Photons
- Characterization of a Shiga Toxin 1-Neutralizing Recombinant Fab Fragment Isolated by Phage Display System
- Different Binding Property of Verotoxin-1 and Verotoxin-2 Against Their Glycolipid Receptor, Globotriaosylceramide
- A Rapid and Simple Detection of Genetic Defects Responsible for the Phenotypic Polymorphism of Cytochrome P450 2C19
- Recombinant Human Monoclonal Fab Fragments against Rotavirus from Phage Display Combinatorial Libraries
- S-C-7. Clinical and Experimental Studies on Whiplash Injury
- Calculation model of CO_2 emission by using a population balance model
- Sum Rules of the Multiple Giant Resonance States(Nuclear Physics)
- A Sum-Rule Constraint on the Soft Dipole Mode
- Cost-Effective Unbiased Straight-Line Fitting to Multi-Viewpoint Range Data (Special Section of Selected Papers from the 9th Karuizawa Workshop on Circuits and Systems)
- Spectra of Neutrons Emitted from Excited/Ground States of ^24,25O
- Spectra of Neutrons Emitted from Excited/Ground States of ^O
- Numerical Simulation of Switching Behavior in Cu/Cu_2S Nanometer-Scale Switch
- A Molecular Dynamics Study of the Energy and Structure of the Symmetric Tilt Boundary of Iron
- Evaluation of low back pain using the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire for lumbar spinal disease in a multicenter study : differences in scores based on age, sex, and type of disease
- Magnetic properties of light neutron-rich nuclei(International Workshop on Nuclear Structure-New Pictures in the Extended Isospin Space(NS07)-)
- Dynamical Effects beyond Mean Field in Drip Line Nuclei
- Syntheses of four possible enantioners of 2, 3-desubstituted-γ-butyrolactones from a single progenitor, (R) -2, 3-O-isopropylideneglyceraldehyde
- STUDY ON RE-ESTABLISHMENT OF OVULATION AFTER TERMINATION OF SEX-STEROIDAL TREATMENT : COMPARED WITH RE-APPEARANCE OF OVULATION AFTER ABORTION AND PREMATURE DELIVERY
- Orientation Relationship in Fcc-Bcc Phase Transformation Kinetics of Iron : a Molecular Dynamics Study
- A Molecular Dynamics Study of Thermodynamic and Kinetic Properties of Solid-Liquid Interface for Bcc Iron
- Electromagnetic Energy Shift of Nucleus between Conducting Plates : Nuclear Physics
- Numerical Simulation of Isothermal Dendritic Growth by Phase-field Model
- Comparison of Calculated Values with Measured Values on the Amount of TRU and FP Nuclides Accumulated in Gadolinium Bearing PWR Spent Fuels
- DESIGN AND SYNTHESIS OF COLON-SPECIFIC PRO-ANTEDRUGS, 20-GLUCOPYRANOSYLOXY METHYLPREDNISOLONATES, FOR ORAL TREATMENT OF ULCERATIVE COLITIS AND THEIR METABOLISM
- Simultaneous determination of lansoprazole enantiomers and their metabolites in plasma by liquid chromatography with solid-phase extraction
- IMMUNOHISTOCHEMICAL INVESTIGATION OF AMINOPEPTIDASE
- IMMUNOHISTOCHEMICAL STUDY ON ARGINASE IN THE BOVIEN LIVER
- IMMUNOHISTOCHEMICAL INVESTIGATION ON THE SEROUS GLAND OF CHICK OVIDUCT : I. ON THE LOCALIZATION OF OVALBUMIN
- LOCALIZATION OF DIAMINE OXIDASE AND D-AMINO ACID OXIDASE IN KIDNEY, DEMONSTRATED BY MEANS OF IMMUNOHISTOCHEMICAL METHOD
- Demosntration of Xanthine Oxidase on the Electron Microscopic Level
- Electron Microscopic Histochemistry of Succinate-ferricyanide Reductase in the Dark Cell of the Chick Liver
- Characterization of debonding energy release rate of FRP sheets bonded on mortar and concrete
- LOCALIZATION OF PAROTIN IN BOVINE PAROTID GLAND, DEMONSTRATED BY THE IMMUNOHISTOCHEMICAL METHOD
- Effects of GABAergic Drugs on the Recovery of Reflex Potentials after Spinal Cord Ischemia in Cats
- Pulmonary Shunting during Venovenous Bypass
- Role of the Landau-Migdal Parameters with the Pseudovector and Tensor Couplings in Relativistic Nuclear Models : The Quenching of the Gamow-Teller Strength(Nuclear Physics)
- The Continuity Equation of RPA
- High Efficiency Gas Cherenkov Counter
- Examination on Biological Activities and Fates of New Steroids, Steroid-17-yl Methyl Glycolate Derivatives
- Immunohistochemical Observation of Antigens in Tissues Embedded in GMA-Quetol 523
- STUDIES ON INFECTION AND THE MULTIPLICATION OF PLANT VIRUSES (III) RELATIONSHIP BETWEEN THE CELL NUCLELTS AND CUCUMBER MOSAIC VIRLTS REPLICATION
- Faceted Crystal Growth of Silicon from Undercooled Melt of Si-20mass%Ni Alloy
- Immunohistochemical Study of Aminopeptidase by Mean of Fluorescent Antibody Technique
- Three-dimensional Phase-field Simulation of Free Dendrite Growth of Iron
- Li^6 and Electron Scattering
- Recognizing tautology by a deterministic algorithm whose while-loop's execution time is bounded by forcing
- Accuracy and Computational Efficiency of Phase-field Models
- Free Dendrite Growth of Fe-0.5mass%C Alloy : Three-dimensional Phase-field Simulation and LKT Model
- Phase-Field Simulation of Free Dendrite Growth of Aluminum-4.5mass%Copper Alloy
- Halo Structure of ^Li and Gamow-Teller Transitions to ^Be
- Numerical Simulation of Initial Microstructure Evolution of Fe-C Alloys Using a Phase-field Model
- Inverse Iteration Method with Multiple Cyclotomically Shifted Parameters
- The effects of gamma aminobutyric acid and gamma hydroxybutyrate upon responses of cat cerebral cortex to direct stimulation (脳と神経の研究-4-(特集))
- Flavonoids isolated from Allium cepa L. var. agrogatum Don(Natural Medicine Note)
- Immunohistochemical study of chick oviduct
- A Molecular Dynamics Study of Bidirectional Phase Transformation between bcc and fcc Iron
- Estimation of Solid-liquid Interfacial Energy from Gibbs-Thomson Effect : A Molecular Dynamics Study
- Gamow-Teller Strengths in Ni Isotopes and Nuclear Weak Processes(YKIS2011 papers, Frontier Issues in Physics of Exotic Nuclei)
- Role of the Landau-Migdal Parameters with the Pseudovector and Tensor Couplings in Relativistic Nuclear Models : The Quenching of the Gamow-Teller Strength(Nuclear Physics)
- Zeta potentials of metal oxides coated with titanate coupling agents in aqueous solution.
- The Solvent Effect on the Electron-Transfer Reactions of Cobalt(III) Complexes. The Reduction of the cis-Chloro-2-aminoethanolbis(ethylenediamine)cobalt(III) Ion by Iron(II) in Aqueous Solutions of Organic Solvents
- An immunohistochemical study of lysozyme in the human nasal mucosa.
- Effects of Naloxone ad Levallorphan on the Spinal Cord Reflex Potentials under the Spinal Ischemic Condition in Cats.
- Gamow-Teller Strengths in Ni Isotopes and Nuclear Weak Processes