The effects of gamma aminobutyric acid and gamma hydroxybutyrate upon responses of cat cerebral cortex to direct stimulation (脳と神経の研究-4-(特集))

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Iwama and Jasper (1957) have described that cortical, topical application of gamma aminobutyric acid (GABA) suppressed surface negative "dendritic " responses to local cortical stimulation in the cat with partial destruction of the brain stem, which surgical operation was done under thiopental anesthesia. Several investigators have studied the effect of GABA on electrical activity of the cerebral cortex, and most of them have carried out topical application of the drug solution. Gelder and Elliott (1958) have reported that GABA does not pass readily the blood-brain barrier, and this fact presumably forced the investigators to apply the substance topically on the cortex. In the present preliminary investigation, we have carefully observed the effects of GABA and gamma hydroxybutyrate (GHB) by intravenous injection or injection into the carotid artery, upon the direct cortical responses to electrical stimuli of the cat's cerebral cortex in unanesthetized, encephale isole preparations. The results were compared with the. potentials obtained in cats anesthetized with pentobarbital.
千葉大学の論文