血圧動揺における中枢性ならびに末梢性因子の解析(<特集>脳と神経の研究)

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1) Various< types of undulation in the systemic blood pressure were observed in curarized cats under artificial respiration. Periodic undulation of blood pressure with a period of the particular type (20-30 seconds with an amplitude of about 10mmHg) was quite frequently observed; this seems to be a new subtype of a third undulation as yet undescribed, and is provisonally designated as an s-wave. A series of s-waves, sometimes accompanied by a non-periodic larger undulation with an amplitude of 35-60 mmHg, which is called a 1-wave, were observed. 2) These s and 1-waves in curarized cats were completely abolished by administration of urethan (1-1, 5g/kg i.m.) within 30 to 45 minutes; both types of waves under the effects of some central depressants were incompletely reduced by bilateral abrenorectomy and blocking of the carotid sinus nerves with local anesthetics. These were however very slightly depressed by a bilateral vagotomy. The waves were always completely abolished by a higher spinal transsection at C_1-C_2. 3) These waves were reinforced by both an increase and decrease of systemic blood pressure produced by administrations of some catecholamines, dopa, acetylcholine, ATP and even glucose solution. Reinforcement was remarkably produced by epinephrine, norepinephrine and acetylcholine, but, not by NaNO_2 or papaverine. 4) The reinforcement of undulation of blood pressure was also elicited by electrical stimuli in some areas of the cerebral cortex, or a central cut end of the vagus, sciatic and femoral nerves. 5) Arousal pattern of the EEG was usually observed a few minutes prior to the appearance of a blood pressure change, and lasted during an increase of blood pressure in each case. This fact indicates that activity of the CNS is closely related to control of the blood pressure, and is also concerned with the function of peripheral receptors. 6) Although there are several reports concerning the central or peripheral origin of undulation of the blood pressure, our results show that its origin is not so as simple as previously stated. Undulation of the blood pressure may be caused not only by activity of medullaly cardiovascular center, which is often modulated from the higher CNS, but also by the activity change of the peripheral receptor. The afferent impulses from the peripheral vascular bed, might be specific. In order to maintain the balance of the internal environment, the efferent impulses to the vascular effector of the whole body are probably non-specific. Thus, the main pathway of both afferent and efferent impulses are presumably in the spinal cord.
千葉大学の論文
1964-09-28

血圧動揺における中枢性ならびに末梢性因子の解析(<特集>脳と神経の研究)

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