Tetrodotoxinによる錘内筋,錘外筋線維の麻痺(<特集>脳と神経の研究)

概要

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When the gastrocnemius nerve was stimulated at the popliteal fossa, a monosynaptic reflex spike was recorded from the central cut end of the ventral root. After intravenous administration of 4 γ/kg tetrodotoxin, contraction of the extensor of the lower extremity reduces but the height of the reflex spike rather enhances. By the aid of tetrodotoxin, the height reduces gradually. The enhancement is due to an increase in discharge frequency of the Group la fiber produced by contraction of the intrafusal muscle fiber elicited, by our repeated stimulation tests. During advancement in paralysis of the extrafusal muscle, height of the reflex spike enhances for 20-30 msec, after stimulation of the distal cut end of the ventral root, and thereafter reduces. The enhancement is due to an increase in the Group la discharge frequency, the decrease to an increase in the Group II discharge. . Paralysis of the skeletal muscle with respect to movement and posture by tetrodotoxin, advances methodically towards the phasic and tonic muscle of the extrafusal muscle, the nuclear-bag and nuclear-chain fibers of the intrafusal muscle, the monosynaptic reflex and nerve fiber.
千葉大学の論文
1964-09-28