末梢神経および筋受容器の再生におよぼすビタミンB1, B6, B12複合体の作用

概要

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Tibial nerve of adult cats was cut at the level of the popliteal fossa and the epineurium of the cut ends was sutured immediately after the cutting with the aid of special rings. Vitamin B1, B6 and B12 complex (B1, 5mg/kg, B6, 5mg/kg and B12, 50γ/kg) were injected i. m. daily for about 80 days, and the effects on nerve regeneration were investigated and compared with components. Greater effects of vitamin B1, B6 and B12 complex than those of its components were as follows. 1) Gastrocnemius muscle tension. 2) Gastrocnemius muscle wt. ratio. 3) Nerve connection of the gastrocnemius muscle spindles and Golgi tendon organs. 4) Decubital ulcer and depilation (greater in decubital ulcer). In the soleus muscle tension and wt. ratio, no such superior effects were observed. The components of vitamin B complex (B1, B6 and B12) did not differ significantly in muscle tension, muscle wt. ratio, decubital ulcer and depilation.
社団法人日本薬理学会の論文