71(PB2-1) アオコMicrocystis viridisの生産する毒素の研究(ポスター発表の部)

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The occurrence of water blooms of cyanobacterium Microcystis in water bodies for public use is becoming a serious problem on the water management and public health, because some causative species are reported to produce toxins. The toxins, whose structures were clarified, were isolated from only M. aeruginosa regarded as the most frequent producer of toxins. In Japan, on the other hand, M. viridis is getting more attentions, because (i) it is the most predominant water-bloom alga at some of the important lakes, which are utilized as reservoirs for water to drink, and (ii) the toxicity of the algal bodies was recently recognized. M. aeruginosa, from which a series of toxins, cyanoginosins, were isolated, was not 'bacteria-free', and the possibility that the toxins thus far isolated were produced by other contaminated microorganisms had not been excluded. This paper describes the structure of a new toxin (1), cyanoviridin RR, isolated from M. viridis, which was cultivated as an axenical clonical culture, and this is the first confirmation that a toxin is actually produced by a Microcystis species. Cyanoviridin RR (1) (70mg) was obtained from the butanol extract of the freeze-dried bodies (100g) of M. viridis, together with other unidentified toxins X (40mg) and Y (20mg). The structure elucidation was performed mainly by means of the modern NMR techniques, such as HOHAHA and ROESY experiments. Of them, the most powerful method was HMBC techniques recently developed by Bax. By analyzing the HMBC spectrum, which exhibited a good number of the informative cross peaks due to long-range couplings between ^<13>C and ^1H depicted in 1, the amino-acid sequence of 1 was determined without ambiguity.
天然有機化合物討論会の論文
1987-07-25

71(PB2-1) アオコMicrocystis viridisの生産する毒素の研究(ポスター発表の部)

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