Syntheses of 24,25-Dihydroxyvitamin D_2, 24,25-Dihydroxy-22-dehydrovitamin D_3, 25-Hydroxy-24-oxo-22-dehydrovitamin D_3 and 22,24,25-Trihydroxyvitamin D_3(Organic,Chemical)

スポンサーリンク

概要

• 論文の詳細を見る

• Four vitamin D_2 and D_3 metabolites, 24,25-dihydroxyvitamin D_2 (8), 24,25-dihydroxy-22-dehydrovitamin D_3 (10). 25-hydroxy-24-oxo-22-dehydrovitamin D_3 (12) and 22,24,25-trihydroxyvitamin D_3 (14), were synthesized from ergosterol (1) via the hydroxyketone (4) as a common key intermediate.

• 公益社団法人日本薬学会の論文
• 1987-03-25

著者

• 小林 正

  Department Of Biochemistry Kobe Gakuin University

• 西村 久美子

  Departments Of Hygienic Sciences Kobe Women's College Of Pharmacy

• 岡野 登志夫

  Department of Hygienic Sciences, Kobe Women's College of Pharmacy

• 内藤 猛章

  神戸女子薬科大学

• 二宮 一彌

  神戸女薬大

• 二宮 一弥

  神戸薬大

• 勝見 琴美

  Departments of Hygienic Sciences, Kobe Women's College of Pharmacy

• 小野 由利枝

  Departments of Hygienic Sciences, Kobe Women's College of Pharmacy

• 前垣 恵美子

  Departments of Hygienic Sciences, Kobe Women's College of Pharmacy

• 馬場 瑞枝

  Departments of Hygienic Sciences, Kobe Women's College of Pharmacy

• 宮田 興子

  Departments of Medicinal Chemistry, Kobe Women's College of Pharmacy

• 内藤 猛章

  Departments of Medicinal Chemistry, Kobe Women's College of Pharmacy

• 二宮 一弥

  Departments of Medicinal Chemistry, Kobe Women's College of Pharmacy

• 勝見 琴美

  Departments Of Hygienic Sciences Kobe Women's College Of Pharmacy

• 馬場 瑞枝

  Departments Of Hygienic Sciences Kobe Women's College Of Pharmacy

• 前垣 恵美子

  Departments Of Hygienic Sciences Kobe Women's College Of Pharmacy

• 小野 由利枝

  Departments Of Hygienic Sciences Kobe Women's College Of Pharmacy

• 内藤 猛章

  神戸薬科大学

• 宮田 興子

  神戸薬科大学

• 岡野 登志夫

  Department of Hygienic Chemistry, Kobe Women's College of Pharmacy

関連論文

• Chelirubine
• 40 Chelirubineの構造と合成
• Studies on 1α-Hydroxyl Derivatives of Vitamin D_3. I. : Syntheses of 1α-Hydroxyvitamin D_3 and 1α, 25-Dihydroxyvitamin D_3
• Photocyclization of Enamides. XXVIII. : A Formal Total Synthesis of (±)-Deserpidine
• 53 ヨヒンビンおよび関連アルカロイドの合成研究
• 101(P-18) ラジカル反応を用いたアミノ酸類の新規不斉合成法の開発(ポスター発表の部)
• Photocyclization of Enamides. XXXVI. Alkaloid Synthesis Using Furopyridone as a Synthon : Synthesis of Key Intermediates for the Synthesis of Eburnamine-Vincamine Alkaloids
• Comparison of 25-Hydroxyvitamin D_3 Binding Proteins from Rat Lymph and Plasma
• Existence of Vitamin D_3 and 25-Hydroxyvitamin D_3 in Rat Lympli
• トリフルオロアセチル基の特性を利用した複素環化合物の効率的合成
• 51 (±)-Pseudodistomin AおよびBの合成研究(口頭発表の部)
• 薬学受験生の意識と大学の対応
• A NEW STEREOSELECTIVE ROUTE TO γ-BUTYROLACTONES : ASYMMETRIC SYNTHESES OF (+)-trans-WHISKY AND (+)-trans-COGNAC LACTONES
• STEREOSPECIFIC NUCLEOPHILIC ADDITION REACTION OF THIOPHENOL TO α, β-UNSATURATED ESTERS
• Photocyclization of Enamides. XXVI. : Photochemical Synthesis of Yohimban, Epiyohimban, and Alloyohimban, Basic Skeletal Structures of Yohimbine- and Reserpine-Type Alkaloids
• P-29 ラジカル付加閉環脱離反応を鍵反応とするMartinelline類の合成研究(ポスター発表の部)
• Bioavailability of Calcium from Calcium Carbonate, DL-Calcium Lactate, L-Calcium Lactate and Powdered Oyster Shell Calcium in Vitamin D-Deficient or -Replete Rats
• Radical Cyclization in Heterocycle Synthesis. II. Total Synthesis of (±)-Anantine and (±)-Isoanatine
• DIASTEREOSELECTIVE SYNTHESIS OF TRIACETYL-L-erythro-C18-SPHINGOSINE
• オキシムエーテル類の簡便なラジカル反応 (特集 ファインケミカルにおけるラジカル反応--グリーンケミストリーをめざして)
• Purification of Vitamin D Binding Proteins (Group-Specific Components) in Human Plasma Using a Chromatofocusing Method
• 109(P42) ラジカル付加・閉環反応を基盤とする天然物の合成研究(ポスター発表の部)
• Photocyclization of Enamides. XXXIII. Total Syntheses of (±)-Agroclavines, (±)-Fumigaclavine B, and (±)-Lysergene
• Photocyclization of Enamides. XXV. : Syntheses of Despyrrole Analogues of Ergot Alkaloids Including Elymoclavine, Lysergol, Isolysergol, Lysergine, Isolysergine, Fumigaclavine, Agroclavine, and Lysergene
• 30 エルゴリン骨格をもつ麦角アルカロイドの全合成
• 23 エナミド光閉環反応による麦角アルカロイドの合成研究
• 60 エナミドの還元的光閉環反応とアルカロイド合成
• 7 Hexahydrobenzo(c)phenanthridine Alkaloidsの合成 : (±)-Corynoline,(±)-12-Hydroxycorynoline,(±)-11-Epicorynoline,(±)-Homochelidonineの全合成
• 57 エナミドを用いたClavine類の合成研究
• 37 エナミド光閉環反応を用いた天然物の合成
• 56 モノテルペノイドイソキノリンおよびインドールアルカロイドの合成
• AN EFFICIENT SYNTHESIS OF (±)-EMETINE USING α, β-UNSATURATED LACTAM AS A MICHAEL ACCEPTOR
• TOTAL SYNTHESES OF (±)-ANANTINE AND (±)-ISOANANTINE VIA THIYL RADICAL ADDITION-CYCLIZATION REACTION
• Efficient synthesis of indoles and benzo〔b〕furans via 〔3,3〕-sigmatropic rearrangement of N-trifluoroacetyl enehydrazines and enehydroxylamines
• P-449 SYNTHESIS OF NATURAL BENZOFURANS BY REAGENT-CONTROLLED DOMINO REACTION
• オキシムエーテル類の固相ラジカル反応
• Synthesis of 2,4-Disubstituted Indoles via Thermal Cyclization of N-Trifluoroacetyl Enehydrazines
• イミン類をラジカル受容体とした反応の開発とその立体制御
• Radical Cyclization of Oxime Ethers Derived from Monosaccharides Aiming at the Synthesis of Dysiherbaine and Related Stereoisomers
• Radical Cyclization in Heterocycle Synthesis(7)Synthesis of Chiral 2-Substituted 5-Amino-4-piperidinols via radical Cyclization
• Photocyclization of Enamides. XXXIV. A Practical Total Synthesis of Aromatic Yohimboid Alkaloids, Oxogambirtannine and Naucleficine
• オレフィンへの立体選択的付加反応
• ICOS(8)フィンランド
• Photocyclization of Enamides. XXXII. : Alkaloid Synthesis Using Furopyridone as a Synthon : Synthesis of Key Intermediates for the Synthesis of (±)-Quinine, (±)-Ajmalicine, and (±)-7-Demethyltecomanine
• インドールアルカロイドの合成研究 : YohimbineおよびErgoline系アルカロイドの合成を中心にして
• Syntheses of 24,25-Dihydroxyvitamin D_2, 24,25-Dihydroxy-22-dehydrovitamin D_3, 25-Hydroxy-24-oxo-22-dehydrovitamin D_3 and 22,24,25-Trihydroxyvitamin D_3(Organic,Chemical)
• SYNTHESIS OF DIASTEREOMERIC 24,25-DIHYDROXYVITAMIN D_2 AND SEPARATION OF ITS (24R)-AND (24S)-ISOMERS
• エナミド閉環反応と複素環合成
• HYDROXIMATE AS A SYNTHETICALLY USEFUL FUNCTIONAL GROUP Part II : SYNTHESIS OF (±)-OXO-PARABENZLACTONE
• エナミド光閉環反応とヘテロ環合成 (ヘテロ環の化学)
• 4.各種ビタミンD関連化合物の結合タンパク質またはリセプターとの結合性の比較(第220回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
• 1-I-13 1α,25-Dihydroxyvitamin D_2のin vitro合成とリセプターに対する結合性(第38回大会研究発表要旨,日本ビタミン学会)
• 24,25-Dihydroxyvitamin D_2の合成及びそのR体,S体の分離 : 日本ビタミン学会第36回大会一般研究発表要旨
• (医)薬品化学の本
• モノテルペノイドインドールアルカロイドの合成
• Plasma Levels of 25-Hydroxyvitamin D2 and 25-Hydroxyvitamin D3 in Maternal, Cord and Neonatal Blood
• ASSAY OF 25-HYDROXYVITAMIN D3 IN HUMAN PLASMA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
• IDENTIFICATION AND DETERMINATION OF 25-HYDROXYVITAMIN D3 IN THE BLOOD AND LIVER OF VITAMIN D-DEFICIENT RATS IRRADIATED WITH ULTRAVIOLET LIGHT
• Simplified Assay of Vitamin D2 in Fortified Dried Milk by Using Two Steps of High-Performance Liquid Chromatography
• STUDIES ON THE ULTRAVIOLET IRRADIATION OF PROVITAMIN D AND ITS RELATED COMPOUNDS III. EFFECT OF WAVELENGTH ON THE FOR-MATION OF POTENTIAL VITAMIN D2 IN THE IRRADIATION OF ERGOSTEROL BY MONO-CHROMATIC ULTRAVIOLET RAYS
• IDENTIFICATION OF VITAMIN D3 AND 7-DEHYDROCHOLESTEROL IN COWS MILK BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND THEIR QUANTITATION BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHYI
• GAS-LIQUID CHROMATOGRAPHIC DETERMINATION OF VITAMIN D IN MULTIVITAMIN PREPARATION
• GAS-LIQUID CHROMATOGRAPHIC DETERMINATION OF VITAMIN D3 IN TUNA LIVER AND VITAMIN D3 RESIN OILS
• GAS-LIQUID CHROMATOGRAPHIC DETERMINATION OF VITAMIN D IN MULTIVITAMIN PREPARATIONS CONTAINING EXCESS AMOUNTS OF VITAMIN E
• A RAPID AND PRECISE METHOD FOR THE DETER-MINATION OF VITAMIN D3 IN RAT SKIN BY NIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
• 共役オキシムエーテル類へのラジカル付加反応を基盤としたドミノ型反応の開発
• An Efficient Synthesis and Selective Reaction of N-Substituted Isothiazolidinium Salts
• Tissue Distribution of 7-Dehydrocholesterol, Vitamin D3 and 25-Hydroxyvitamin D3 in Several Species of Fishes
• EFFECT OF WAVELENGTH ON THE FORMATION OF 1α-HYDROXYPREVITAMIN D3 IN THE ULTRAVIOLET IRRADIATION OF CHOLESTA-5, 7-DIENE-1α, 3β-DIOL AND USE OF A FILTER SOLUTION IN THE PHOTOCHEMICAL REACTION IN THE SYNTHESIS OF 1 α-HYDROXY-VITAMIN D3
• 共役オキシムエーテル類へのラジカル付加反応を基盤としたドミノ型反応の開発
• Photochemical conversion of 7-dehydrocholesterol into vitamin D3 in rat skins.
• In vivo and in vitro conversion of 7-dehydrocholesterol into vitamin D3 in rat skin by ultraviolet ray's irradiation.
• Studies on the biogenesis of vitamin D. I. Identification and determination of 7-dehydrocholesterol in rat skin.
• A method for simultaneous determination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human plasma by using two steps of high-performance liquid chromatography.
• Variation of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 levels in human plasma obtained from 758 Japanese healthy subjects.
• Synthesis and biological activity of 5,6-trans-vitamin D3 in anephric rats.
• Isolation and purification of in vivo-generated 25-hydroxyvitamin D2 by preparative high-performance liquid chromatography.
• Studies on the Ultraviolet Irradiation of Provitamin D and Its Related Compounds:II. Determination of Potential Vitamin D2 in Ultraviolet Irradiated Products of Ergosterol by Gas-Liquid Chromatography
• Decomposition of Vitamin D by the Hydroperoxide Formed from 2, 6-Di-tert-butyl-4-methylphenol during Alkali Saponification
• STUDIES ON THE ISOMERIZATION OF VITAMIN D AND RELATED COMPOUNDS WITH ACIDIC REAGENTS:I. A SIMPLE METHOD FOR THE DETERMINA-TION OF VITAMIN D2 ISOMERS IN MIXTURES
• An improved procedure for the isolation of suprasterol2 I and II from a photochemical reaction mixture of ergocalciferol (vitamin D2).
• Lack of evidence for existence of vitamin D and 25-hydroxyvitamin D sulfates in human breast and cow's milk.
• Effect of wavelength on the photochemical reaction of ergocalciferol (vitamin D2) irradiated by monochromatic ultraviolet light.
• STUDIES ON THE ISOMERIZATION OF VITAMIN D AND RELATED COMPOUNDS WITH ACIDIC REAGENTS:II. MECHANISM OF THE ISOMERIZATION OF VITAMIN D2 AND ITS ISOMERS WITH BORON TRIFLUORIDE
• Bone marrow and serum concentrations of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, and 1.ALPHA.,25-dihydroxyvitamin D in patients with leukemia and normal subjects.
• High-performance liquid chromatographic determination of vitamin D3 in bovine colostrum, early and later milk.
• Protein-binding properties of 22-oxa-1.ALPHA.,25-dihydroxyvitamin D3, a synthetic analogue of 1.ALPHA.,25-dyhydroxyvitamin D3.
• Change in blood vitamin levels in surgical patients given a multivitamin preparation (NK-041) for total parenteral nutrition.
• Effect of Solvents on the Thermal Isomerization of 1α-Hydroxyprevitamin D3 Diacetate to 1α-Hydroxyvitamin D3 Diacetate
• The physicochemical and immunological characteristics of rat lymph binding protein for 25-hydroxyvitamin D3.
• Changes in the concentrations of vitamin D and its metabolites in the plasma of healthy subjects orally given physiological doses of vitamin D2 by multivitamin or vitamin D preparations.
• High-performance liquid chromatographic determination of vitamin D in foods, feeds and pharmaceuticals by successive use of reversed-phase and straight-phase columns.
• High-performance liquid chromatographic determination of vitamin D3 in fish liver oils and eel body oils.
• Concentrations of vitamin D-binding protein and vitamin D metabolites in plasma of patients with liver cirrhosis.

もっと見る 閉じる

スポンサーリンク