GAS-LIQUID CHROMATOGRAPHIC DETERMINATION OF VITAMIN D IN MULTIVITAMIN PREPARATIONS CONTAINING EXCESS AMOUNTS OF VITAMIN E

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Gas-liquid chromatographic (GLC) determination of vitamin D in multivitamin preparations containing excess amounts of vitamin E (a more than 2, 500 weight ratio of dl-α-tocopheryl acetate to vitamin D) was investigated and a simplified routine method was esta blished because the method reported previously (l) could not be applied to such special preparations. After applying the unsaponifiable matters of a sample to a phosphate-treated alumina column chromatography pre pared according to MULDER et al. (2), the eluate was evaporated and the residue was subjected to thin-layer chromatography (TLC) and GLC. When this method was applied to model preparations made by mixing vitamin D2 and dl-α-tocopheryl acetate (excess amounts), good results were obtained. Since the results on a commercial multivitamin prepara tion containing excess amounts of vitamin E were also satisfactory, it was confirmed that the proposed method could be used for simplified routine determinations.
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