Plasma Levels of 25-Hydroxyvitamin D2 and 25-Hydroxyvitamin D3 in Maternal, Cord and Neonatal Blood

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概要

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• A high-performance liquid chromatographic method for simultaneous assay of 25-hydroxyvitamin D2 (25-OH-D2) and 25 hydroxyvitamin D3 (25-OH-D3) proposed in a previous paper (1) was applied to determine the plasma levels of the metabolites in perinatal and postnatal periods. The plasma samples of maternal, cord and neonatal blood were collected in summer and winter seasons. 25-Hydroxyvitamin D3 was detected in all the samples. The plasma levels of the metabolite in mothers, cords and newborn infants (at life within 24hr) in summer were 33.9±12.5, 18.9±8.4 and 16.6±6.4 (mean±S. D.) ng/ml, respectively, while those in winter were 15.8±6.6, 8.8±3.4 and 7.7±3.2 ng/ml, respectively. The data in summer were significantly higher than the respective data in winter and there were high significant correlations between mothers and cords and between mothers and newborns. In both seasons, the plasma levels of mothers were about two times higher than the respective dataa of cords and newborns which were nearly identical with one another. The similar tendency was always observed in the individual data of mothers-cords-newborns pair samples. In this study, many plasma samples from mothers, cords and newborns were examined, but 25-OH-D2 was detected in only few samples (6/41 for mothers, 3/36 for cords and 2/34 for newborns). However, the metabolite began to appear in all the samples during nursing with vitamin D2-fortified dry milk to show 4.6±1.3 and 4.8±1.2 ng/ml in the summer and winter samples of neonates at life of 5-6 days, respectively. When the variation of plasma 25-OH-D2 and 25-OH-D3 levels was examined in postnatal periods until one month, the levels of exogenous 25-OH-D2 was increased while those of endogenous 25-OH-D3 was decreased. The sum of vitamin D2 intake from fortified dry milk was highly significantly correlated with the plasma levels of 25-OH-D2, which indicates that daily intake of exogenous vitamin D2 is very important in nutrition during postnatal periods of bottle-fed infants.

• 財団法人 学会誌刊行センターの論文

著者

• 小林 正

  Department Of Biochemistry Kobe Gakuin University

• 黒田 英造

  神戸大医小児科

• 松尾 保

  Department of Pediatrics Kobe University School of Medicine

• 岡野 登志夫

  Department of Hygienic Sciences, Kobe Women's College of Pharmacy

• 黒田 英造

  Department of Pediatrics, Kobe University School of Medicine

• 水野 直子

  Department of Hygienic Chemistry, Kobe Womens College of Pharmacy

• 児玉 荘一

  Department of Pediatrics, Kobe University School of Medicine

• 二宮 道人

  Department of Pediatrics, Kobe University School of Medicine

• 森下 順彦

  Department of Pediatrics, Kobe University School of Medicine

• 水野 直子

  Department of Hygienic Chemistry, Kobe Women's College of Pharmacy

• 岡野 登志夫

  Department of Hygienic Chemistry, Kobe Women's College of Pharmacy

• 小林 正

  Department of Hygienic Sciences, Kobe Women's College of Pharmacy

• 小林 正

  Department of Hygienic Scfences, Kobe Women's College of Pharmacy

関連論文

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• 3.新生児期,乳児期の血中25-OH-D_2及び25-OH-D_3レベルの消長 : 脂溶性ビタミン総合研究委員会第191回会議研究発表要旨
• 1-II-20 ヒト血漿中の25-OH-D_2並びに25-OH-D_3のレベルについて : 日本ビタミン学会第33回大会研究発表要旨
• 3. 健康人血漿中の25-OH-D_2並びに25-OH-D_3の濃度変動 : 脂溶性ビタミン総合研究委員会第190回会議研究発表要旨
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• 5.母乳並びに牛乳中のビタミンD_3の定量 : 脂溶性ビタミン総合研究委員会第186回会議研究発表要旨
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