Protein-binding properties of 22-oxa-1.ALPHA.,25-dihydroxyvitamin D3, a synthetic analogue of 1.ALPHA.,25-dyhydroxyvitamin D3.
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概要
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Protein binding properties of 22-oxa-lα, 25-dihydroxyvitamin D3(22-oxa-1, 25-D3), a synthetic analogue of 1α, 25-dihydroxyvitamin D3(1, 25-D3), were compared with those of vitamin D3derivatives. The order of binding affinity to the chick embryonic intestinal receptor was 1, 25-D3>22-oxa-1, 25-D3>25-hydroxyvitamin D3(25-D3) >24R, 25-dihydroxyvitamin D3(24, 25-D3) >vitamin D3(D3), while that to the rat plasma vitamin D-binding protein (DBP) was 25-D3>24, 25-D3>D3>1, 25-D3>22-oxa-1, 25-D3. The binding potencies of 22-oxa-1, 25-D3to the receptor and DBP were about 1/8 and 1/600 of the respective values of 1, 25-D3. When the distribution of the tritiated compounds in human plasma components was examined by an in vitro polyacrylamide gel electrophoretic method, [3H]-22-oxa-1, 25-D3was found to bind only to the lipoproteins including chyromicron. These results suggest that the replacement of a carbon atom into an oxygen atom in the side chain structure of 1, 25-D3results significant decrease in the binding affinity to DBP and that 22-oxa-1, 25-D3is transported as a complex-form not with DBP but with lipoprotein to the target tissues.
- 財団法人 学会誌刊行センターの論文
著者
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小林 正
Department Of Biochemistry Kobe Gakuin University
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西井 易穂
Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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増田 園子
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
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津川 尚子
Department of Hygienic Sciences, Kobe Pharmaceutical University
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竹内 敦子
Department of Hygienic Scfences, Kobe Women's College of Pharmacy
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岡野 登志夫
Department of Hygienic Chemistry, Kobe Women's College of Pharmacy
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西井 易穂
Research Laboratories of Chugai Pharmaceutical Co., Ltd.
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増田 園子
Department of Hygienic Sciences, Kobe Women's College of Pharmacy
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