1252 ナノスケールで制御した材料上における細胞の接着挙動(J03-1 細胞の構造と流れのメカニクス(1),J03 細胞の構造と流れのメカニクス)

概要

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Bio-environment designing is the key factor for successful tissue engineering technology. In this study, the relationship between the cell adhesion behavior and the nano surface topography, which is controlled by dynamic oblique deposition, has been discussed. The SiO_2 films with flat, cylinder and bundle nano surface topographies were deposited on a glass substrate. The aspect ratio of cylinder morphology was about 1.2 and spacing between each cluster of column is about 100nm. The aspect ratio and spacing of bundle morphology was about 2.2 and 50-100nm, respectively. Mesenchymal cells derived form adipose tissue were seeded on the sample and then adhesion area and circularity cells were observed. The cells cultured on the flat surface showed the higher adhesion area. However there was not the significant difference in circularity.
社団法人日本機械学会の論文
2005-09-18