719 異なるバインダー樹脂を用いたPLA繊維複合材料の生分解特性(OS1-2 生分解性ポリ乳酸とポリ乳酸系複合材料の変形と破壊)

概要

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We developed novel fabric structural composite scaffolds using a bioabsorbable polymer for a regeneration of alveolar bone. The composites consist of the high strength poly (L-lactide) fiber fabric and the bioabsorbable polymer coating. To clarif,' the biodegradable properties of scaffolds, two kinds of resins (polyε-caprolactone and poly (DL-lactide-co-glycolide) copolymer) as a coating binder are employed. For the evaluation of biodegradation and cell growth, mouse osteoblastic cell (MC3T3-E1) seeded in a scaffold was cultured in vitro for eight weeks. As a result, the rigidity and yield strength of PLGA coating scaffold that had a membrane structure between fibers was large increase compared with PCL coating scaffold. However, DNA content per unit area as a cell proliferation and ALP activity per unit DNA as the regeneration activities were about the same to each resin.
一般社団法人日本機械学会の論文
2007-10-24