Correlation Between the TH1 and TH2 Cells by Intracellular Cytokine Detection and MLR-blocking Antibodies in Patients with Unexplained Recurrent Abortion

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概要

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• Objectives: This study elucidated the correlation among blocking antibodies as detected by means of a mixed lymphocyte culture reaction (MLR) between spouses (MLR-BAbs), type I helper T cells (TH1), and type II helper T cells (TH2) in patients with unexplained recurrent abortions. Study design: Forty-five patients with unexplained recurrent abortions were chosen as a study population. Cells with TH1 and TH2 were determined by detecting intracellular interferon (IFN) -gamma and interleukin-4 (IL-4) production. The percentage of TH1 cells, TH2 cells, and the TH1/TH2 ratio were compared between MLR-BAbs-positive group and -negative group. The correlation between MLR-blocking effect and TH1 cells, TH2 cells, and TH1/TH2 ratio were also analyzed. Results and conclusion: Of 45 patients, 12 were positive for MLR-BAbs (MLR-BAbs positive group) and 33 were negative for MLR-BAbs (MLR-BAbs negative group). Although the percentage of TH2 cells was not significantly different between the two groups, the percentages of TH1 cells and the TH1/TH2 ratio were significantly higher in patients with negative MLR-BAbs compared with those positive for MLR-BAbs. Moreover, the MLR-blocking effect showed a significant negative correlation with the TH1/TH2 ratio in the patient population. Thus, it is suggested that the BAbs evaluated by MLR between spouses might reflect the TH1/TH2 balance in patients with unexplained recurrent abortion.

• 新潟大学の論文

著者

• TANAKA Kenichi

  Department of Physics, School of Medicine, Sapporo Medical University

• Takakuwa Koichi

  Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sc

• Takakuwa Koichi

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• KURABAYASHI Takumi

  Department of Obstetrics and Gynecology, Niigata University School of Medicine

• Kurabayashi T

  Department Of Obstetrics And Gynecology Niigata City General Hospital

• Kurabayashi Takumi

  新潟大学 医歯総研究国際感染医学

• Kurabayashi Takumi

  Division Of Obstetrics And Gynecology Department Of Obstetrics And Gynecology Niigata University Gra

• Tamura Masaki

  Department of Respiratory Medicine, Kyorin University School of Medicine

• Tanaka K

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• ISHII Keisuke

  Department of Materials Science and Engineering, The National Defense Academy

• Mitsui Takuya

  Department Of Obstetrics And Gynecology Niigata University Graduate School Of Medical And Dental Sci

• Ishii Keisuke

  Department Of Obstetrics And Gynecology Niigata University Graduate School Of Medical And Dental Sci

• Ishii Keisuke

  Department Of Materials Science And Engineering The-national Defense Academy

• Ishi Keisuke

  Department Of Materials Science And Engineering The National Defense Academy

• Tamura Masaki

  Department Of Health Check-up Pl Tokyo Health Care Center

• Tamura M

  Department Of Obstetrics Andgynecology Niigata University School Of Medicine

• Ishii K

  Nanoelectronics Research Institute National Institute Of Advanced Industrial Science And Technology

• Tanaka K

  Department Of Gastrointestinal And Paediatric Surgery Mie University Graduate School Of Medicine

• Honda Keisuke

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• Tanaka Kenichi

  Department Of Physics School Of Medicine Sapporo Medical University

• Tanaka Kenichi

  Department Of Electronic And Bioinformatics School Of Science Technology Meiji University

• Ishii Keisuke

  Department Of Electrical Engineering Waseda University

• Tanaka Kenichi

  Department Of Anesthesiology Emory University School Of Medicine

• Ishii Keisuke

  Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University

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