Compatibility of HLA-A and -B Antigens in Patients with Unexplained Recurrent Abortion

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概要

• 論文の詳細を見る

• To elucidate whether there is significant compatibility of HLA class I antigens between spouses of unexplained recurrent abortion in the Japanese population, HLA-A and -B antigens were determined by a microcytotoxicity method in 122 patient couples with unexplained recurrent abortion and in 60 normal fertile couples. The 122 patients were divided into primary recurrent aborters and secondary recurrent aborters. They were also divided according to positivity of the MLR (mixed lymphocyte culture reaction)- blocking antibodies (MLR-BAbs). The numbers of incompatible antigens in those couples with unexplained recurrent abortion were determined and compared with those in the control couples. The mean numbers of incompatible HLA-A and -B antigens in couples with recurrent aborters (n=122), and control couples (60) were 2.67±0.97, and 2.83±0.93, respectively, indicating no significant different. The mean numbers of incompatible HLA-A and -B antigens in couples with primary recurrent aborters (n=106) and secondary recurrent aborters (n=16) were 2.68±0.98, and 2.63±1.02, respectively. These numbers were not significantly different compared with those in the control couples. Those in couples with negative MLR-BAbs (n=105) and with positive MLR-BAbs (n=17) were 2.70±0.66 and 2.53±1.07, respectively, values which were also not significantly different compared with those in the normal control couples. These findings suggest that the compatibility of HLA-A and -B antigens between couples is not involved in the genesis of unexplained recurrent abortions in the Japanese population.

• 新潟大学の論文

著者

• KIKUCHI Akira

  Department of Hematology/Oncology, Saitama Children's Medical Center

• TANAKA Kenichi

  Department of Physics, School of Medicine, Sapporo Medical University

• Takakuwa Koichi

  Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sc

• Takakuwa Koichi

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• KURABAYASHI Takumi

  Department of Obstetrics and Gynecology, Niigata University School of Medicine

• Kurabayashi T

  Department Of Obstetrics And Gynecology Niigata City General Hospital

• Kurabayashi Takumi

  新潟大学 医歯総研究国際感染医学

• Kurabayashi Takumi

  Division Of Obstetrics And Gynecology Department Of Obstetrics And Gynecology Niigata University Gra

• Tamura Masaki

  Department of Respiratory Medicine, Kyorin University School of Medicine

• Tanaka K

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• ISHII Keisuke

  Department of Materials Science and Engineering, The National Defense Academy

• Mitsui Takuya

  Department Of Obstetrics And Gynecology Niigata University Graduate School Of Medical And Dental Sci

• Ishii Keisuke

  Department Of Obstetrics And Gynecology Niigata University Graduate School Of Medical And Dental Sci

• Ishii Keisuke

  Department Of Materials Science And Engineering The-national Defense Academy

• Ishi Keisuke

  Department Of Materials Science And Engineering The National Defense Academy

• Tamura Masaki

  Department Of Health Check-up Pl Tokyo Health Care Center

• Tamura M

  Department Of Obstetrics Andgynecology Niigata University School Of Medicine

• Ishii K

  Nanoelectronics Research Institute National Institute Of Advanced Industrial Science And Technology

• YOKOO Tomokazu

  Department of Obstetrics and Gynecology, Niigata University School of Medicine

• HONDA Keisuke

  Department of Obstetrics and Gynecology, Niigata University School of Medicine

• KAIBE Mamiko

  Department of Obstetrics and Gynecology, Niigata University School of Medicine

• Kaibe Mamiko

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• Tanaka K

  Department Of Gastrointestinal And Paediatric Surgery Mie University Graduate School Of Medicine

• Honda Keisuke

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• Honda Keisuke

  Department Of Chemical Technology Tokyo Institute Of Technology

• Yokoo Tomokazu

  Department Of Obstetrics And Gynecology Niigata University School Of Medicine

• Kikuchi Akira

  Department Of Biochemistry Hiroshima University School Of Medicine

• Akira Kikuchi

  Department Of Obstetrics And Gynecology Niigata University Graduate School Of Medical And Dental Sci

• Tanaka Kenichi

  Department Of Physics School Of Medicine Sapporo Medical University

• Tanaka Kenichi

  Department Of Electronic And Bioinformatics School Of Science Technology Meiji University

• Ishii Keisuke

  Department Of Electrical Engineering Waseda University

• Tanaka Kenichi

  Department Of Anesthesiology Emory University School Of Medicine

• Kikuchi Akira

  Department Of Biochemistry Graduate School Of Biomedical Science Hiroshima University

• Ishii Keisuke

  Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University

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