Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer
スポンサーリンク
概要
- 論文の詳細を見る
The human homolog of the Drosophila prune protein (from PRUNE, which encodes h-prune), which interacts with glycogen synthase kinase 3, promotes cellular motility. H-prune also interacts with nm23-H1, a suppressor of cancer metastasis. It has been reported that stimulation of cellular motility by h-prune is enhanced by its interaction with nm23-H1 in breast cancer cells. In the present study, we examined the expression of h-prune and nm23-H1 during tumor progression in gastric cancer (GC). PRUNE mRNA was overexpressed in 12 (32%) of 38 GC cases by quantitative reverse transcription-polymerase chain reaction. PRUNE mRNA levels correlated significantly with advanced T grade, N grade and tumor stage. Immunohistochemical analysis revealed that 43 (30%) of 143 GC cases were positive for h-prune, and h-prune-positive GC cases showed more advanced T grade, N grade and tumor stage than h-prune-negative GC cases. One hundred and twenty-four (87%) of 143 GC cases were positive for nm23-H1, and nm23-H1 was expressed in almost all (42 cases, 98%) h-prune-positive GC cases. Many GC cases positive for both h-prune and nm23-H1 showed more advanced T grade, N grade and tumor stage than other type GC cases. Patients with h-prune-positive GC had a significantly worse survival rate than patients with h-prune-negative GC. These findings indicate that overexpression of h-prune is associated with tumor progression and aggressiveness of GC. nm23-H1 may enhance motility of cancer cells by interacting with h-prune. (Cancer Sci 2007; 98: 1198-1205)
- Blackwell Publishingの論文
- 2007-08-10
著者
-
Suzuki K
Department Of Urology Gunma University Graduate School Of Medicine
-
KIKUCHI Akira
Department of Hematology/Oncology, Saitama Children's Medical Center
-
Araki Kazuhiro
千葉大学フロンティアメディカル工学研究開発センター
-
YOSHIDA Kazuhiro
Department of Surgical Oncology, Gifu University
-
Komiya A
Department Of Urology Graduate School Of Medicine And Pharmaceutical Sciences For Research Universit
-
Komiya Akira
富山大学 医学薬学研究部腎泌尿器科学
-
Komiya Akira
Department Of Urology Chiba University Graduate School Of Medicine
-
YASUI Wataru
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences
-
Oue Naohide
Department Of Molecular Pathology Hiroshima University Graduate School Of Biomedical Sciences
-
Suzuki Keita
Environmental Health Sciences Tohoku University Graduate School Of Medicine
-
Yasui W
Department Of Molecular Pathology Hiroshima University Graduate School Of Biomedical Sciences
-
Yasui Wataru
Department Of Molecular Pathology Graduate School Of Biomedical Sciences Hiroshima University
-
Suzuki Maki
東北大学 医系研究 障害科学 専攻 高次機能障害学 分野
-
Noguchi Tsuyoshi
Department Of Oncological Science (surgery Ii) School Of Medicine Oita University
-
Noguchi Tsuyoshi
Department Of Gastrointestinal Surgery Oita University Faculty Of Medicine
-
Kakehi Yoshiyuki
Department Of Urology Kyoto University Graduate School Of Medicine
-
Suyama Kazuho
Department Of Urology Kitasato University School Of Medicine
-
Suyama Kazuho
Departments Of Urology Kitasato University School Of Medicine
-
Komiya Akira
Department Of Urology Chiba University School Of Medicine
-
Kikuchi Akira
Department Of Biochemistry Hiroshima University School Of Medicine
-
Yoshida Kazuhiro
Department Of Surgical Oncology Gifu Graduate School Of Medicine
-
Yoshida Kazuhiro
Department Of Biotechnology Graduate School Of Engineering Nagoya University
-
SENTANI Kazuhiro
Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences
-
Suyama Kazuho
Department Of Urology Shintoshi Clinic
-
Kakehi Yoshiyuki
Department Of Urology Kagawa University Graduate School Of Medicine
-
Kunishima Yasuharu
Department Of Urology Sapporo Medical University School Of Medicine
-
Kotani Yoshiyuki
Manufacturing Technology Development Division Electronic Device Group Fujitsu Limited
-
Kadono Yoshifumi
Department Of Urology Kanazawa University Hospital
-
Kadono Yoshifumi
Department Of Urology Kanazawa University School Of Medicine
-
Sentani Kazuhiro
Department Of Molecular Pathology Hiroshima University Graduate School Of Biomedical Sciences
-
Suzuki Kazuo
Gunma University
-
Kato Akira
Space Systems Dept. Komukai Works Toshiba Corporation
-
OUE Naohide
Hiroshima University
-
Kikuchi Akira
Department Of Biochemistry Graduate School Of Biomedical Science Hiroshima University
関連論文
- Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children
- Massive Pericardial and Pleural Effusion With Anasarca Following Allogeneic Bone Marrow Transplantation
- Oral analgesia by non-steroidal anti-inflammatory drug zaltoprofen to manage cystoscopy-related pain : A prospective study
- Usefulness of panoramic views for novice surgeons doing retroperitoneal laparoscopic nephrectomy
- Renal cell carcinoma with a huge solitary metastasis to the contralateral adrenal gland : A case report
- The role of testosterone in the pathogenesis of prostate cancer
- The efficacy and safety of laparoscopic nephrectomy in patients with three or more comorbidities
- Baseline health-related quality of life in the management of prostate cancer
- The usefulness of ureterorenoscopic examination of evaluation of upper tract disease
- Expression of Thymidine Phosphorylase in Primary Human Renal Cell Carcinoma by ELISA Method
- Epigenetic Regulation of the KAI1 Metastasis Suppressor Gene in Human Prostate Cancer Cell Lines
- Prostate adenocarcinoma producing syndrome of inappropriate secretion of antidiuretic hormone
- Endocrine therapy for recurrence after definitive radiotherapy in patients with prostate cancer
- Changes in serum prostate-specific antigen following prostatectomy in patients with benign prostate hyperplasia
- Value free-to-total prostate-specific antigen ratio for detection and staging of prostate cancer
- Association between clinical stage of prostate cancer and pathological findings of random systematic transperineal core biopsy under transrectal ultrasonography
- External beam radiation monotherapy for prostate cancer
- HELLP Syndrome, Multiple Liver Infarctions, and Intrauterine Fetal Death in a Patient with Systemic Lupus Erythematosus and Antiphospholipid Syndrome
- Three Distinct Commonly Deleted Regions of Chromosome Arm 16q in Human Primary and Metastatic Prostate Cancers
- Localization of a Tumor Suppressor Gene Associated With Progression of Human Prostate Cancer Within a 1.2 Mb Region of 8p22-p21.3
- Screening of Epithelial Cell-Adhesive Peptides from Fibronectin Loop Region and Its Cell Specificity
- Direct Intratumoral Gene Transfer of the Herpes Simplex Virus Thymidine Kinase Gene with DNA-liposome Complexes: Growth Inhibition of Tumors and Lack of Localization in Normal Tissues
- Neuroendocrine differentiation in the progression of prostate cancer
- Effect of androgen deprivation therapy on quality of life in Japanese men with prostate cancer
- Clinical significance of urinary white blood cell count and serum C-reactive protein level for detection of non-palpable prostate cancer
- Changes in prostate volume in Japanese patients with benign prostatic hyperplasia : Association with other urological measures and risk of surgical intervention
- Permanent Waving Does not Change Mercury Concentration in the Proximal Segment of Hair Close to Scalp
- Guidelines for urological laparoscopic surgery
- Morbidity of laparoscopic radical prostatectomy : Summary of early multi-institutional experience in Japan
- WS3-6 Prediction of pathological stage and biochemical recurrence after radical prostatectomy for clinically resectable prostate cancer in Japanese men
- Suppression of STAT3 Activity by Duplin, Which Is a Negative Regulator of the Wnt Signal
- Malignant fibrous histiocytoma of the right spermatic cord : A case report
- Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) Assay for Simultaneous Measurement of Salivary Testosterone and Cortisol in Healthy Men for Utilization in the Diagnosis of Late-onset Hypogonadism in Males
- Single Nucleotide Polymorphism Analysis of the Follicle-stimulating Hormone (FSH) Receptor in Japanese with Male Infertility : Identification of Codon Combination with Heterozygous Variations of the Two Discrete FSH Receptor Gene
- CD69-null mice protected from arthritis induced with anti-type II collagen antibodies
- Surgical outcome of laparoscopic radical prostatectomy : summary of early multiinstitutional experience in Japan
- Transurethral En Bloc Resection of an Urachal Cyst
- A simple and reliable monitoring system to confirm the preservation of the cavernous nerves
- Expression and Degradation of Rat Androgen Receptor Following Castration, Testosterone Replacement and Antiandrogens Administration : Analysis by Western Blot and Immunohistochemistry
- Evidence-based Clinical Practice Guidelines for Prostate Cancer : Summary - JUA 2006 Edition
- Preliminary results of a monitoring system to confirm the preservation of cavernous nerves
- Effect of Annealing on Superconductivity in Bi-Pb-Sr-Ca-Cu-O System
- Influence of Cooling Rate on Superconducting Characteristics of Bi-Pb-Sr-Ca-Cu-O Ceramics
- Superconducting Characteristics and Microstructure of Bi-Pb-Sr-Ca-Cu-O Ceramics : Electrical Properties of Condensed Matter
- Effects of rat Axin domains on axis formation in Xenopus embryos
- Abscess formation due to Mycoplasma hominis infection after cesarean section
- Compatibility of HLA-A and -B Antigens in Patients with Unexplained Recurrent Abortion
- Proprostate-specific antigen : Its usefulness in the era of multiple-core prostate biopsy
- Gene Expression Profiles of Prostate Cancer Cell Lines, LNCaP, PC-3 and DU-145, Assessed by cDNA Microarray
- Clinical validity of proliferating cell nuclear antigen as an objective marker for evaluating biologic features in patients with untreated prostate cancer
- Incidence of Bladder Cancer Discovered by Urethrocystoscopy at Prostate Biopsy : Extraordinary High Incidence of Tiny Bladder Cancer in Elderly Males
- Role of Androgen on Blood Flow and Capillary Structure in Rat Seminal Vesicles
- Effects of Aspirin-dialminate on Suppression in the Serum Phosphorus Levels in Patients Treated with Hemodialysis
- Genomewide linkage analysis of familial prostate cancer in the Japanese population
- Ultrastructural Changes in Subepithelial Capillaries and Their Surrounding Stroma in Rat Prostate and Seminal Vesicle after Castration
- Intraarterial Infusion of Lipiodol CDDP Suspension into the Internal Iliac Artery : Pre Clinical Dose Escalation Study Using Canine Model
- Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population
- Intermittent Deep Coma in a Hemodialysis Patient with Liver Cirrhosis : A Case Report
- Autopsy findings of patients with urological neoplasms
- Usefulness of prostate-specific antigen velocity in screening for prostate cancer
- Usefulness of PSA screening in outpatients with bladder cancer : Preliminary results
- Tumor-associated tissue eosinophilia of penile cancer
- Three Pedigrees of Hereditary Prostate Cancer
- Epstein-Barr virus-encoded latent membrane protein 1 activates β-catenin signaling in B lymphocytes
- Treatment outcome by risk group after radical prostatectomy in Japanese men
- Trends in Growth Status among Schoolchildren in Sendai, Japan, 1994-2003 : Leveling-Off of Mean Body Height and Weight
- Transurethral Balloon Laser Thermotherapy for Benign Prostatic Hyperplasia
- Transurethral Balloon Laser Thermotherapy: Effects of a Directionally Shielded Balloon in Canine Prostates
- Histological and Immunohistochemical Changes after Transurethral Balloon Laser Hyperthermia in the Canine Prostate
- TRANSURETHRAL BALLOON LASER HYPERTHERMIA FOR CHRONIC NON-BACTERIAL PROSTATITIS: A CLINICAL TRIAL
- THERMAL DAMAGE TO NORMAL AND HYPERPLASTIC PROSTATES DUE TO TRANSURETHRAL BALLOON LASER THERAPY IN DOGS
- TUMOR FORMATION BY GENETIC MUTATIONS OF β-CATENIN, APC, AND AXIN IN THE WNT SIGNALING PATHWAY
- Tumor formation due to abnormalities in the β-catenin-independent pathway of Wnt signaling
- The Second Joint Meeting of American Urological Association (AUA)/Japanese Urological Association (JUA) International Program on the 102nd Annual Meeting of American Urological Association at Anaheim 2007
- Processing and Superconducting Properties of GdBa_2Cu_3O_ Ceramics : Electrical Properties Condensed Matter
- Influence of Preparative Conditions on the Superconducting Characteristics in GdBa_2Cu_3O_ Ceramics : Electrical Properties of Condensed Matter
- Observation of GdBa_2Cu_3O_ Ceramic Microstructure : Electrical Properties of Condensed Matter
- Updated Japanese Urological Association Guidelines on prostate-specific antigen-based screening for prostate cancer in 2010
- Ubiquitin-Interacting Motifs of Epsin Are Involved in the Regulation of Insulin-Dependent Endocytosis
- Inhibition of the Canonical Wnt Signaling Pathway in Cytoplasm : a Novel Property of the Carboxyl Terminal Domains of Two Xenopus ELL Genes(Developmental Biology)
- Familial Prostate Cancer in Four Brothers
- Effect of Sex Hormones on the Tissue Localization of Nuclear Estrogen Receptor Positively Stained Cells in the Seminal Vesicle of Immature Castrated Rats
- Significance of Measurement of Prostate Specific Antigen (PSA) in Familial Prostate Cancer Lines
- Eosinophils Infiltration in the Rat Seminal Vesicle Associated with Estradiol-17β-Related Stromal Proliferation
- Lateral view dissection of the prostato-urethral junction to reduce positive apical margin in laparoscopic radical prostatectomy
- Delayed recovery of urinary continence after laparoscopic radical prostatectomy
- Immunohistochemical Demonstration of Metallothionein in the Rat Epididymis and Spermatic Cord(Endocrinology)
- Serial analysis of gene expression of esophageal squamous cell carcinoma : ADAMTS16 is upregulated in esophageal squamous cell carcinoma
- Transcriptome dissection of gastric cancer : Identification of novel diagnostic and therapeutic targets from pathology specimens
- Increased expression of h-prune is associated with tumor progression and poor survival in gastric cancer
- Retrospective study on stage B prostate cancer in the Hokuriku District, Japan
- Cranial nerve deficit caused by skull metastasis of prostate cancer: three Japanese castration-resistant prostate cancer cases
- Establishment of reference ranges for ductus venosus waveform indices in the Japanese population
- Regulation of Type 1 Protein Phosphatase/Inhibitor-2 Complex by Glycogen Synthase Kinase-3β in Intact Cells
- METALLOTHIONEIN IN HUMAN SEMINAL PLASMA
- Immunostaining of gastric cancer with neuroendocrine differentiation : Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, pancreatic polypeptide and somatostatin
- Advancements in Urology 2011 : A Japanese Urological Association (JUA)/American Urological Association (AUA) Symposium
- Myelodysplastic syndrome treated effectively with testosterone enanthate
- Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution
- Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis