Cranial nerve deficit caused by skull metastasis of prostate cancer: three Japanese castration-resistant prostate cancer cases

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概要

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• We report 3 Japanese patients with cranial nerve deficit caused by skull metastasis of prostate cancer (PCa). Case 1 was a 75-year-old patient with a chief complaint of diplopia. The cause of diplopia was right oculomotor nerve palsy from the skull metastasis. External beam radiation therapy (EBRT) to the whole brain, 40 Gy in 20 fractions, was performed and the diplopia improved. Case 2 was a 72-year-old patient with a chief complaint of facioplegia. Bone scintigraphy and computed tomography (CT) of the head revealed right occipital bone metastasis of PCa resulting in right facial nerve palsy. EBRT to the right occipital bone, 50 Gy in 25 fractions, with daily oral dexamethasone (DEX) was performed and facioplegia showed complete recovery. At 12 months after onset, the patient was followed-up with no symptoms. Case 3 was a 74-year-old patient with a chief complaint of diplopia. Diffusion-weighted magnetic resonance imaging (MRI) and positron emission tomography (PET) showed right petrous bone metastasis resulting in right abducent nerve palsy. EBRT to the right petrous bone, 44 Gy in 22 fractions, with oral DEX was performed and diplopia showed complete recovery. At 13 months after onset, the patient was followed-up with no symptoms. MRI and PET may detect PCa metastasis in the skull base more clearly than other imaging modalities. EBRT with 40-50 Gy in 20-25 fractions in association with corticosteroid administration may be reasonable treatment of patients with metastatic PCa who develop cranial nerve dysfunction. © 2010 Japan Society of Clinical Oncology.

• Springer Verlag (Germany)の論文
• 2010-12-01

著者

• Suzuki K

  Department Of Urology Gunma University Graduate School Of Medicine

• KOH Eitetsu

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical

• SUGIMOTO Kazuhiro

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical

• NAMIKI Mikio

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Eitetsu Kou

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Suzuki Keita

  Environmental Health Sciences Tohoku University Graduate School Of Medicine

• Suzuki Maki

  東北大学 医系研究 障害科学 専攻 高次機能障害学 分野

• MIZOKAMI Atsushi

  Department of Urology

• Namiki Mikio

  Department Of Integrated Cancer Therapy And Urology Kanazawa University Graduate School

• Mizokami Atsushi

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Mizokami Atsushi

  Department Of Urology Kanazawa University Graduate School Of Medical Science

• Namiki Mikio

  Department Of Applied Physics And Science And Engineering Research Laboratory Waseda University

• Suyama Kazuho

  Department Of Urology Kitasato University School Of Medicine

• Suyama Kazuho

  Departments Of Urology Kitasato University School Of Medicine

• Namiki Mikio

  Department Of Integrated Cancer Therapy And Urology Andrology Unit Kanazawa University Graduate Scho

• Mizokami Atsushi

  Department Of Urology Kanazawa University Hospital

• NARIMOTO Kazutaka

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical

• IZUMI Kouji

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical

• Koh Eitetsu

  Department Of Integrated Cancer Therapy And Urology Andrology Unit Kanazawa University Graduate Scho

• Kitamura Eiko

  Life Science Advanced Research Institute For The Sciences And Humanities Nihon University

• Suyama Kazuho

  Department Of Urology Shintoshi Clinic

• Sugimoto Kazuhiro

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Sugimoto Kazuhiro

  Department Of Applied Chemistry Shibaura Institute Of Technology

• Izumi Kouji

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• KUMANO Tomoyasu

  Department of Radiology, Kanazawa University Graduate School of Medical Science

• Kumano Tomoyasu

  Department Of Radiology Kanazawa University Graduate School Of Medical Science

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Narimoto Kazutaka

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Izumi Kouji

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Namiki Mikio

  Department Of Urology Kanazawa University Graduate School Of Medical Science

• Mizokami Atsushi

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Sentani Kazuhiro

  Department Of Molecular Pathology Hiroshima University Graduate School Of Biomedical Sciences

• Sugimoto Kazuhiro

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Namiki Mikio

  Department Of Applied Physics : Science And Engineering Research Laboratory Waseda University

• Mizokami Atsushi

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Naoi Makito

  Department Of Urology Toho University Sakura Medical Center

• Suzuki Kazuo

  Gunma University

• Izumi Kouji

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science

• Mizokami Atsuhi

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science

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