Bisphosphonate induces apoptosis and inhibits pro-osteoclastic gene expression in prostate cancer cells

スポンサーリンク

概要

• 論文の詳細を見る

• Aim: Bisphosphonates are well established for the management of cancer-induced skeletal complications. Recent studies suggest that bisphosphonates promote apoptosis of cancer cells as well as osteoclasts in bone metastatic sites. To determine the direct effects of bisphosphonate on prostate cancer, we examined the effects of minodronate on prostatic cancer cell growth and the expression of apoptosis-related proteins and osteoclastogenic factors. Methods: PC-3, DU145 and LNCaP cells were treated with amino-bisphosphonate minodronate. Then proliferation, apoptosis and expression of bcl-2, bax, poly (ADP)-ribose polymerase (PARP), caspase-3, receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinases-2 (MMP-2), and parathyroid hormone related protein (PTHrP) were assessed. Results: The proliferation of prostatic cancer cells was inhibited by minodronate. DNA fragmentation and TUNEL-positive nuclei were observed in minodronate-treated PC-3 cells. Minodronate decreased bcl-2 expression and induced bax expression, caspase-3 activity and degradation of PARP in DU145 and PC-3 cells. Minodronate decreased expression of RANKL, PTHrP and MMP-2 in PC-3 cells. Conclusions: Our results suggest that bisphosphonate not only promotes apoptosis directly but also decreases pro-osteoclastic gene expression in prostate cancer cells.

• Blackwell Publishingの論文
• 2006-05-01

著者

• NAMIKI Mikio

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical

• Kohno K

  Department Of Molecular Biology School Of Medicine University Of Occupational And Environmental Heal

• Kohno Kimitoshi

  九州大学 医学系研究院 医化学

• Kohno Kimitoshi

  Department Of Molecular Biology University Of Occupational And Environmental Health School Of Medici

• Koshiba Ken

  Departments Of Urology And Pathology Kitasato University School Of Medicine

• Keller Evan

  Department Of Urology University Of Michigan

• KOSHIDA Kiyoshi

  Department of Urology, School of Medicine, Kanazawa University

• Koshida Kiyoshi

  Department Of Urology Kanazawa University Hospital

• MIZOKAMI Atsushi

  Department of Urology

• ASAHI HIDEKI

  Department of Urology, School of Medicine, Kanazawa University

• MIWA SOTARO

  Department of Urology, School of Medicine, Kanazawa University

• Mizokami Atsushi

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Mizokami Atsushi

  Department Of Urology Kanazawa University Graduate School Of Medical Science

• Namiki Mikio

  Department Of Applied Physics And Science And Engineering Research Laboratory Waseda University

• Miwa Sotaro

  Department Of Urology Kouseiren Takaoka Hospital

• Miwa Sotaro

  Department Of Urology School Of Medicine Kanazawa University

• Asahi Hideki

  Department Of Urology School Of Medicine Kanazawa University

• Namiki Mikio

  Department Of Integrated Cancer Therapy And Urology Andrology Unit Kanazawa University Graduate Scho

• Koshida Kiyoshi

  Department Of Urology Graduate School Of Medicine Kanazawa University

• Mizokami Atsushi

  Department Of Urology Kanazawa University Hospital

• Koshida Kiyoshi

  Department Of Urology Kanazawa University School Of Medicine

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Kondo Katsuyoshi

  Department Of Urology Okayama Red Cross General Hospital

• Namiki Mikio

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Namiki Mikio

  Department Of Urology Kanazawa University Graduate School Of Medical Science

• Mizokami Atsushi

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Namiki Mikio

  Department Of Applied Physics : Science And Engineering Research Laboratory Waseda University

• Mizokami Atsushi

  Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical

• Miwa Sotaro

  Department Of Urology Kanazawa University Hospital

• Koshida Kiyoshi

  Department Of Molecular Biology School Of Medicine University Of Occupational And Environmental Health

• Koshiba Ken

  Department Of Molecular Biology University Of Occupational And Environmental Health

• Mizokami Atsuhi

  Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science

関連論文

• Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1
• Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis
• THE BASIC AND CLINICAL IMPLICATIONS OF ABC TRANSPORTERS, Y-BOX-BINDING PROTEIN-1 (YB-1) AND ANGIOGENESIS-RELATED FACTORS IN HUMAN MALIGNANCIES
• Measurement-specific bioavailable testosterone using concanavalin A precipitation : Comparison of calculated and assayed bioavailable testosterone
• Detection of drug-resistant Escherichia coli in patients with complicated cystitis : Analysis of risk factors
• Histopathological approach to prostatic contour alterations with the concept of left-right asymmetry
• Preclinical Cushing's syndrome: Report of seven cases and a review of the literature
• Electromagnetic Form Factors of Deuteron at Large Momentum Transfers in the Covariant Oscillator Quark Model : Particles and Fields
• Structure Functions of Electron-Deuteron Elastic Scattering and Deuteron Magnetic Moment in Relativistic Quark Model
• Deuteron Elastic Electromagnetic Form Factor in Relativistic Harmonic Oscillator Model
• Four year clinical statistics of iridium-192 high dose rate brachytherapy
• Induction of Necrosis by Zinc in Prostate Carcinoma Cells and Identification of Proteins Increased in Association with This Induction.
• High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer
• Immunolocalization of Anti-placental Alkaline Phosphatse Monoclonal Antibody in Mice with Testicula Tumors and Lymph Node Metastasis.
• Separation and Identification of Urinary Proteins Following Digital Rectal Examination in Patients with Benign Prostatic Hypertrophy.
• Factors Contributing to Imaging of Xenografts Using Anti-placental Alkaline Phosphatase Monoclonal Antibody.
• Chemotherapy of Metastatic Testicular Germ Cell Tumors: Relationship of Histologic Response to Size Reduction and Changes in Tumor Markers
• Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest
• Single Solitary Metastasis of the Slowly Progressive Type of Renal Cell Carcinoma to the Choroid Plexus : Case Report
• Hormonal therapy
• Prognostic significance of UDP-N-acetyl-α-D-galactosamine : polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma
• Y-box binding protein-1 is a novel molecular target for tumor vessels
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) Assay for Simultaneous Measurement of Salivary Testosterone and Cortisol in Healthy Men for Utilization in the Diagnosis of Late-onset Hypogonadism in Males
• Single Nucleotide Polymorphism Analysis of the Follicle-stimulating Hormone (FSH) Receptor in Japanese with Male Infertility : Identification of Codon Combination with Heterozygous Variations of the Two Discrete FSH Receptor Gene
• Multicentric papillary renal cell carcinoma associated with renal adenomatosis
• Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression on human prostate cancer cells
• Overexpression of Multidrug Resistance Protein Gene in Human Cancer Cell Lines Selected for Drug Resistance to Epipodophyllotoxins
• Stones in Polycystic Kidneys : Results of Treatment by Extracorporeal Shock Wave Lithotripsy
• Extracorporeal Shock Wave Lithotripsy of Staghorn Stones in Solitary Kidneys
• Biomodulation by Hyperthermia of Topoisomerase II-Targeting Drugs in Human Colorectal Cancer Cells
• Heparin-binding Epidermal Growth Factor-like Growth Factor: p91 Activation, Induction of Plasminogen Activator/Plasminogen Activator Inhibitor, and Tubular Morphogenesis in Human Microvascular Endothelial Cells
• Bisphosphonate induces apoptosis and inhibits pro-osteoclastic gene expression in prostate cancer cells
• Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo
• In vitro chemosensitivity test for human genito-urinary tumors using collagen gel matrix
• Comparison of two in vivo models for prostate cancer : Orthotopic and intratesticular inoculation of LNCaP or PC-3 cells
• Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma
• Pathological effects of neoadjuvant hormonal therapy help predict progression of prostate cancer after radical prostatectomy
• Potential benefits of combining cytosine deaminase/5-fluorocytosine gene therapy and irradiation for prostate cancer : Experimental study
• Case of mediastinal seminoma with testicular microlithiasis
• Efficacy of primary hormonal therapy for patients with localized and locally advanced prostate cancer : A retrospective multicenter study
• Prospective study of combined treatment with interferon-alpha and active vitamin D_3 for Japanese patients with metastatic renal cell carcinoma
• Giant Retroperitoneal Cyst in an Adult Male
• Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype
• Sentinel node navigation surgery using endoscopic minilaparotomy technique for patients with prostate cancer
• Y chromosome and new concept of azoospermia factor
• Spermatogenic ability is different among males in different Y chromosome lineage
• Langevin Simulation of a Bottomless Hermitian Matrix Model for Two Dimensional Quantum Gravity : Particles and Fields
• Stabilization of φ^3-Model Based on Stochastic Quantization Method with Kerneled Langevin Equation : Particles and Fields
• New Procedure of Numerical Simulation of Long-Range Correlations and Energy Gaps by Stochastic Quantization : Fixed Potential Model and O(3) Nonlinear σ-Model : Particles and Fields
• Numerical Simulation of Nonlinear σ-Model by Means of Stochastic Quantization Method : Particles and Fields
• Stochastic Quantization of Constrained Systems : General Theory and Nonlinear Sigma Model : Particles and Fields
• Gauge Fixing Condition as Non-Holonomic Constraint in Stochastic Quantization of Non-Abelian Gauge Fields
• Equivalence of Stochastic Quantization Method to Conventional Field Theories through Super Transformation Invariance
• Stochastic Quantization of Non-Abelian Gauge Field : Unitarity Problem and Faddeev-Popov Ghost Effects
• Free-to-total prostate-specific antigen (PSA) ratio contributes to an increased rate of prostate cancer detection in a Japanese population screened using a PSA level of 2.1-10.0ng/ml as a criterion
• Electromagnetic Spectrum from QGP Fluid
• Numerical Analyses of CERN 200 GeV/A Heavy-Ion Collisions Based on a Hydrodynamical Model with Phase Transition
• Public Awareness and Knowledge of Prostate Cancer in Japan: Results of a Survey at Short-Stay Examination Facilities
• High Intensity Focused Ultrasound Using Prototype Sonablate^ and New Type Sonablate-200^ for Treating Benign Prostatic Hyperplasia
• Long-Term Outcome of Continuous 3-day Intravesical Instillation Therapy with Bleomycin for Prophylaxis of Superficial Bladder Cancer Recurrence : A Comparative Study
• Absence of a Mutation of the Ras Genes in Human Prostate Cancer
• A Non-Randomized Comparative Study of Visual Laser Ablation and Transurethral Resection of the Prostate in Benign Prostatic Hyperplasia
• Boson Electromagnetic Vertex Function in the Veneziano Model
• A Prospective Comparative Trial of a Gonadotropin-Releasing Hormone Analogue with Clomiphene Citrate for the Treatment of Oligoasthenozoospermia
• NEW INDICATION OF TESTIS BIOPSY FOR AZOOSPERMIA : A CLINICAL STUDY IN JAPANESE PATIENTS
• Isolated Hyperkalemia Associated with Cyclosporine Administration in Allogeneic Stem Cell Transplantation for Renal Cell Carcinoma
• Modified anatrophic partial nephrectomy with selective renal segmental artery clamping to preserve renal function : A preliminary report
• Bilateral epididymal sarcoidosis presenting without radiographic evidence of intrathoracic lesion : Review of sarcoidosis involving the male reproductive tract
• Intrarenal varix mimicking a cystic renal tumor
• Current concepts of human azoospermia and its causes
• Azoospermia factor and male infertility
• Adrenal androgen levels as predictors of outcome in castration-resistant prostate cancer patients treated with combined androgen blockade using flutamide as a second-line anti-androgen
• Transport Theory for Quark-Gluon Plasma based on an Operator Field Langevin Equation
• Gauge Invariant Quantum Electrodynamics with the Mass-Changing Minimal Current
• Prevalence of human papillomavirus infection in the urinary tract of men with urethritis
• Perturbation Theory of Relativistic Eigenvalue Problem
• Formal Theory of Green Functions
• Pion-Nucleon Backward Scattering at High Energies and Pion Structure
• Role of protein kinase C in central muscannic mechanisms regulating voiding in rats
• A Variational Method for Determination on the Propagation Parameter
• Applicability Conditions of the Hydrodynamical Model of Multiple Production of Particles from the Point of View of Quantum Field Theory
• A Possible Scheme of Elementary Particle Structure : Trion Model with Integral Quantum Numbers and Additional Force-Field
• On the Transient Phenomena in the Wave Guide
• Quark Model and πN Backward Scatterings
• Complete Renormalization Scheme for Fictitious-Time Correlations in Stochastic Quantization Method Based on Operator Formalism : Particles and Fields
• Stochastic Quantization Method in Operator Formalism
• Short Distance Interaction Effects in Elastic Differential Cross Section of High Energy Hadron-Nucleus Collisions
• Possible Nonvanishing Mass of Photon : Particles and Fields
• Massive Abelian Gauge Fields Coupled with Nonconserved Currents : Renormalization Scheme : Particles and Fields
• Phenomenological Analysis of Z^0→l^^-l Decay on Excited Lepton Hypothesis
• Successful treatment for metastases from renal cell carcinoma with alternation of interferon-alpha subtypes
• What Does the Boson Missing Mass Spectrum Reveal? : Speculative Arguments and Phenomenological Analyses on Hadron Level Structure
• Gross Structure of High Energy Multiple Productions : The t-Cut Phase Volume Distributions
• Neutron Interference Experiments and Quantum Measurement Theory
• Proposed Photon Interference Experiment for Test of Quantum Measurement Theories
• Possible Derivation of Energy Gaps or Hadron Masses from Fictitious-Time Correlations in Stochastic Quantization Method : Particles and Fields
• Retrospective study on stage B prostate cancer in the Hokuriku District, Japan
• Late-onset hypogonadism (LOH) and androgens : Validity of the measurement of free testosterone levels in the diagnostic criteria in Japan
• Cranial nerve deficit caused by skull metastasis of prostate cancer: three Japanese castration-resistant prostate cancer cases
• Hydrodynamical Expansion of Viscous QGP Fluid with Phase Transition : Particles and Fields

もっと見る 閉じる

スポンサーリンク