Four year clinical statistics of iridium-192 high dose rate brachytherapy
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概要
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Background: We evaluated the efficacy and complications of high dose rate (HDR) brachytherapy using iridium-192 (192Ir) combined with external beam radiotherapy (EBRT) in patients with prostate cancer. Methods: Ninety-seven patients underwent 192Ir HDR brachytherapy combined with EBRT at our institution between February 1999 and December 2003. Of these, 84 patients were analysed in the present study. 192Ir was delivered three times over a period of 2 days, 6 Gy per time, for a total dose of 18 Gy. Interstitial application was followed by EBRT at a dose of 44 Gy. Progression was defined as three consecutive prostate-specific antigen (PSA) rises after a nadir according to the American Society for Therapeutic Radiology and Oncology criteria. The results were classified into those for all patients and for patients who did not undergo adjuvant hormone therapy. Results: The 4-year overall survival of all patients, the nonadjuvant hormone therapy group (NAHT) and the adjuvant hormone therapy group (AHT) was 87.2%, 100%, and 70.1%, respectively. The PSA progression-free survival rate of all patients, NAHT, and AHT was 82.6%, 92.0%, and 66.6%, respectively. Of all patients, the 4-year PSA progression-free survival rates of PSA < 20 and PSA ≥ 20 groups were 100%, and 46.8%, respectively. According to the T stage classification, PSA progression-free survival rates of T1c, T2, T3, and T4 were 100%, 82.8%, 100%, and 12.1%, respectively. Prostate-specific antigen progression-free survival rates of groups with Gleason scores (GS) < 7 and GS ≥ 7 were 92.8% and 60.1%, respectively. Of NAHT, PSA progression-free survival of PSA < 20 was 100% vs 46.8% for PSA ≥ 20, that of T1c was 100% vs 75% for T2, and that of GS < 7 was 100% vs 75% for GS ≥ 7. No significant intraoperative or postoperative complications requiring urgent treatment occurred except cerebellum infarction. Conclusions: 192Ir HDR brachytherapy combined with EBRT was as effective as radical prostatectomy and had few associated complications。
- 2006-02-01
著者
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NAMIKI Mikio
Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical
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SHIGEHARA Kazuyoshi
Department of Urology, Nanto Central Hospital
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Shigehara Kazuyoshi
Ishikawa Prefectural Central Hospital Department Of Urology
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Shigehara Kazuyoshi
Department Of Urology Nanto Central Hospital
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Shigehara Kazuyoshi
Department Of Urology Kanazawa University Hospital
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Kohno K
Department Of Molecular Biology School Of Medicine University Of Occupational And Environmental Heal
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Kohno Kimitoshi
九州大学 医学系研究院 医化学
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Kohno Kimitoshi
Department Of Molecular Biology University Of Occupational And Environmental Health School Of Medici
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Koshiba Ken
Departments Of Urology And Pathology Kitasato University School Of Medicine
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KOSHIDA Kiyoshi
Department of Urology, School of Medicine, Kanazawa University
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Koshida Kiyoshi
Department Of Urology Kanazawa University Hospital
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MIZOKAMI Atsushi
Department of Urology
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KOMATSU Kazuto
Department of Urology
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Kunimi Kazuto
Department Of Urology Fukui Red Cross Hospital
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Mizokami Atsushi
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Mizokami Atsushi
Department Of Urology Kanazawa University Graduate School Of Medical Science
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Komatsu Kazuto
Department Of Urology Fukui Red Cross Hospital
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Namiki Mikio
Department Of Applied Physics And Science And Engineering Research Laboratory Waseda University
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Namiki Mikio
Department Of Integrated Cancer Therapy And Urology Andrology Unit Kanazawa University Graduate Scho
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Koshida Kiyoshi
Department Of Urology Graduate School Of Medicine Kanazawa University
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Shigemura Katsumi
Division Of Urology Department Of Surgery Kobe University Graduate School Of Medicine
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Mizokami Atsushi
Department Of Urology Kanazawa University Hospital
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Shigehara Kazuyoshi
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Sawada Kiyoshi
Department Of Urology Municipal Tsuruga Hospital
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Katagiri Kazuko
Departments Of Immunology Kurume University School Of Medicine
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Koshida Kiyoshi
Department Of Urology Kanazawa University School Of Medicine
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Namiki Mikio
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Kondo Katsuyoshi
Department Of Urology Okayama Red Cross General Hospital
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Namiki Mikio
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Namiki Mikio
Department Of Urology Kanazawa University Graduate School Of Medical Science
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Mizokami Atsushi
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Namiki Mikio
Department Of Applied Physics : Science And Engineering Research Laboratory Waseda University
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Mizokami Atsushi
Department Of Integrative Cancer Therapy And Urology Kanazawa University Graduate School Of Medical
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Koshida Kiyoshi
Department Of Molecular Biology School Of Medicine University Of Occupational And Environmental Health
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Koshiba Ken
Department Of Molecular Biology University Of Occupational And Environmental Health
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Mizokami Atsuhi
Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
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