V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation
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概要
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Candidate gene SNP study is a promising genetic approaches to complex common disorders. Argininevasopressin （AVP）, a peptide hormone released from the posterior pituitary, has been suggested to play importantroles in the regulation of blood pressure, glycogenolysis and platelet aggregation through G protein coupled V1areceptor （V1aR）. Thus, polymorphisms in the V1aR gene have been prospective as possible genetic markers foressential hypertension, type 2 diabetes mellitus and divergent platelet aggregation response to AVP. We identifi ed 4novel single nucleotide polymorphisms（ SNPs） in the promoter region of the V1aR gene and named according to theupstream locations such as, -6951G/A, -4112A/T, -3860T/C, and -242C/T. We investigated the association of 4 SNPs ofthe V1aR gene in 365 hypertensive and 255 healthy subjects, 186 T2DM patients and 188 non-diabetic control subjects（CS）, and 33 young healthy volunteers living in the Aomori prefecture. Signifi cant association was identifi ed betweenSNP at -6951 and hypertension in nonobese individuals, at -6951 and type 2 diabetes mellitus. Positive association wasalso identifi ed between nonobese hypertension and haplotype H3. Signifi cant association was demonstrated betweenSNP at -6951 and glycemic status in young healthy subjects. However, there was no signifi cant association in the AVPinducedplatelet aggregation with V1aR gene variants. The study suggests V1aR gene variants as increased riskfor hypertension in nonobese and type 2 diabetes mellitus in the Aomori population; however, might not be useful asgenetic markers for platelet aggregation heterogeneity.
著者
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SUGIMOTO Kazuhiro
Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical
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Yasujima Minoru
Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine
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Yasujima M
Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine
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Yasujima Minoru
岐阜大学 医学部第3内科
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SAITO Junko
Department of Obstetrics and Gynecology, Osaka University Medical School
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Yasujima Minoru
Department Of Laboratory Medicine Hirosaki University School Of Medicine
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SHOJI Masaru
Department of Laboratory Medicine, Hirosaki University School of Medicine
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NAKAJI SHIGEYUKI
Department of Public Health, Hirosaki University School of Medicine
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Hasan Kazi
Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine
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Saito Junko
Department Of Biology Faculty Of Education Yamanashi University
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Saito Junko
Department Of Clinical Laboratory Hirosaki University Hospital
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Shoji Masaru
Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine
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Suda Toshihiro
Department Of Endocrinology And Metabolism Hirosaki University Graduate School Of Medicine
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TSUTAYA Shoji
Department of Laboratory Medicine, Hirosaki University School of Medicine
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Matsuda Eriko
Department of Clinical Laboratory, Hirosaki University Hospital
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Kudo Ryoko
Department of Clinical Laboratory, Hirosaki University Hospital
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Nakaji Shigeyuki
Department Of Hygiene Hirosaki University School Of Medicine
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Nakaji Shigeyuki
Department Of Social Medicine Hirosaki University Graduate School Of Medicine
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Kudo Ryoko
Department Of Clinical Laboratory Hirosaki University Hospital
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Matsuda Eriko
Department Of Clinical Laboratory Hirosaki University Hospital
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Tsutaya Shoji
Department Of Clinical Laboratory Hirosaki University Hospital
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Sugimoto Kazuhiro
Department Of Applied Chemistry Shibaura Institute Of Technology
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Sugimoto Kazuhiro
Department Of Clinical Laboratory Hirosaki University Hospital
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Nakaji Shigeyuki
Hirosaki Univ. Graduate School Of Medicine
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Yasujima Minoru
Department Of Clinical Laboratory Hirosaki University Hospital
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