Depressive State and Paresthesia Dramatically Improved by Intravenous MgSO_4 in Gitelman's Syndrome
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概要
- 論文の詳細を見る
A 69-year-old woman was referred to our department for evaluation of hypokalemia, which had been treated by oral potassium for more than ten years. She complained of headache, knee joint pain, sleeplessness and paresthesia in extremities and, most prominently, depression. Laboratory data suggested Gitelman’s syndrome, which is caused by mutations in the gene encoding the thiazide-sensitive Na-Cl cotransporter. Direct sequencing of the gene in this patient revealed homozygous mutation R964Q in exon 25. Intravenous supplement of MgSO4 dramatically improved both the depression and the paresthesia, suggesting that hypomagnesemia played a role in the clinical manifestations.
- 社団法人 日本内科学会の論文
- 2004-05-01
著者
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Yasujima Minoru
Department Of Laboratory Medicine Hirosaki University Graduate School Of Medicine
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Yasujima Minoru
Department Of Laboratory Medicine Hirosaki University School Of Medicine
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MUNE TOMOATSU
Third Department of Medicine, Gifu University School of Medicine
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Yasuda K
Department Of Endocrinology Diabetes And Rheumatology Gifu University School Of Medicine
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ENYA Mayumi
Third Department of Internal Medicine, Gifu University School of Medicine
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KANOH Yoshinori
Third Department of Internal Medicine, Gifu University School of Medicine
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ISHIZAWA Masayoshi
Third Department of Internal Medicine, Gifu University School of Medicine
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SARUI Hiroshi
Third Department of Internal Medicine, Gifu University School of Medicine
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YAMAMOTO Mayumi
Third Department of Internal Medicine, Gifu University School of Medicine
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TAKEDA Noriyuki
Third Department of Internal Medicine, Gifu University School of Medicine
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YASUDA Keigo
Center for Lifestyle-Related Diseases, Matsunami General Hospital
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TSUTAYA Shoji
Department of Laboratory Medicine, Hirosaki University School of Medicine
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TAKEDA Jun
Third Department of Internal Medicine, Gifu University School of Medicine
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Yamamoto Mayumi
Third Department Of Internal Medicine Gifu University School Of Medicine
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Ishizawa Masayoshi
Third Department Of Internal Medicine Gifu University School Of Medicine
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Mune Tomoatsu
Third Department Of Medicine Gifu University School Of Medicine
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TAKEDA Noriyuki
Department of Internal Medicine, Murakami Memorial Hospital
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Yasuda Keigo
Department Of Endocrinology Diabetes And Rheumatology Gifu University School Of Medicine
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Matsuhisa Takashi
Department Of Neurosurgery Matsunami General Hospital
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Yoshino Kouji
Third Department Of Internal Medicine Gifu University School Of Medicine
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Enya Mayumi
Third Department Of Internal Medicine Gifu University School Of Medicine
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Sarui Hiroshi
Department Of Internal Medicine Murakami Memorial Hospital Asahi University
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Sarui Hiroshi
Third Department Of Internal Medicine Gifu University School Of Medicine
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Tsutaya Shoji
Department Of Clinical Laboratory Hirosaki University Hospital
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Tsutaya Shoji
Department Of Laboratory Medicine Hirosaki University School Of Medicine
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Takeda Noriyuki
Department Of Internal Medicine Murakami Memorial Hospital
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Kusuda Yoichiro
First Department Of Internal Medicine Oita Medical University School Of Medicine
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Murai Toshihiro
The Department Of Internal Medicine Matsunami General Hospital
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Takeda Jun
Third Department Of Internal Medicine Gifu University School Of Medicine
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Mune Tomoatsu
Third Department Of Internal Medicine Gifu University School Of Medicine
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Yasujima Minoru
Department Of Clinical Laboratory Hirosaki University Hospital
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