Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy
スポンサーリンク
概要
- 論文の詳細を見る
- 2013-06-01
著者
-
Metoki Norifumi
Department Of Internal Medicine Hirosaki Stroke Center
-
Osanai Tomohiro
Department Of Cardiology Hirosaki University Graduate School Of Medicine
-
Nishizaki Fumie
Department Of Cardiology Hirosaki University Graduate School Of Medicine
-
Tomita Hirofumi
Department Of Cardiology Hirosaki University Graduate School Of Medicine
-
Yasujima Minoru
Department Of Clinical Laboratory Hirosaki University Hospital
-
Sukekawa Takanori
Department Of Cardiology Hirosaki University Graduate School Of Medicine
-
Sukekawa Takanori
Department of Cardiology, Hirosaki University Graduate School of Medicine
-
Okumura Ken
Department of Advance Management of Cardiac Arrhythmias Hirosaki University Graduate School of Medicine
-
KAMADA Takaatsu
Department of Internal Medicine, Hirosaki Stoke and Rehabilitation Center
-
MAGOTA Koji
Asubiio Pharma Co., Ltd.
-
HAGII Joji
Department of Internal Medicine, Hirosaki Stoke and Rehabilitation Center
関連論文
- Adenosine-Induced Dilation of Coronary Resistance Vessels Is Impaired in Rats with Type 2 Diabetes Mellitus: Possible Role of ATP-Sensitive Potassium Channels and Nitric Oxide
- PJ-002 Nidorandil Decreases Plasma Level of Matrix Metallproteinase Activity and Attenuates Left Ventricular Remodeling in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-3 (IHD) PJ1,Poster Session (Japane
- Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats
- ＜Symposium V＞Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation
- Retinoic acid-inducible gene-I（ RIG-I） and diseases
- Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia
- Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) : Digest Version
- THE ROLE OF RENAL PROSTAGLANDIN E AND KALLIKREIN IN PATHOGENESIS OF ESSENTIAL HYPERTENSION
- Renoprotective Effect of Angiotensin-Converting Enzyme Inhibitor Combined with α_1-Adrenergic Antagonist in Spontaneously Hypertensive Rats with Renal Ablation
- Glucocorticoidal Regulation of Pituitary Vasopressin Content in Rats
- Cardiac Angiotensin Converting Enzyme and Endothelin Receptor in Rats With Chronic Myocardial Infarction
- PLASMA RENIN ACTIVITY IN ESSENTIAL HYPERTENSION, WITH SPECIAL REFERENCE TO ITS CHANGES UNDER THE INFLUENCE OF SPIRONOLACTONE AND PROPRANOLOL : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation
- A Case of Gitelman's Syndrome with Decreased Angiotensin II-Forming Activity
- Elevated Plasma Brain Natriuretic Peptide Levels Independent of Heart Disease in Acute Ischemic Stroke : Correlation with Stroke Severity
- PJ-567 Plasma Brain Natriuretic Peptide Level is Elevated in Acute Ischemic Stroke Independently of Heart Disease : Correlation with Stroke Severity(Cerebrovascular circulation/Stroke-3, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
- PPAR-gamma Ligands Inhibit Shear Stress-induced Release of a Novel Vasoconstrictor Coupling Factor 6 : Role of Nuclear Factor-kappa B(Endothelium/NO 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-382 Roxithromycin directly inhibits proliferation of human coronary artery smooth muscle cells : a potential ability to prevent restenosis(Restenosis after Angioplasty, Basic/Clinical 3 (IHD) : OJ46)(Oral Presentation (Japanese))
- Role of Nuclear Factor-κ B in Shear-Induced Release of Coupling Factor 6 and the Effect of Peroxisome Proliferator-Activated Receptor γ Ligand
- Depressive State and Paresthesia Dramatically Improved by Intravenous MgSO_4 in Gitelman's Syndrome
- Effect of Chronic Neutral Endopeptidase Inhibition on Cardiac Hypertrophy after Experimental Myocardial Infarction
- Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells : a role of acidosis-induced c-Src activation
- OJ-062 Vasoconstrictor Coupling Factor 6 Downregulates Platelet / Endothelial Cell Adhesion Molecule-1 Expression via Activation of c-Src and Acts as a Proatherogenic Molecule(Endothelium-2, The 71st Annual Scientific Meeting of the Japanese Circulation S
- Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
- 15-Deoxy- ^-Prostaglandin J_2 Inhibits the IL-1β-Induced Expression of Granulocyte-Macrophage Colony-Stimulating Factor in BEAS-2B Bronchial Epithelial Cells
- PJ-325 Non-genomic Vasoconstrictor Effect of Aldosterone in the Mouse Mesenteric Arterioles : Interaction With Angiotensin II type 1 Receptor Signaling(Hypertension, basic(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- PJ-324 Pivotal Role of Transglutaminase in Non-genomic Vasoconstrictor Effect of Aldosterone : Dimerization of Angiotensin II Type 1 Receptor in Smooth Muscle(Hypertension, basic(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Ja
- OE-242 Amiodarone Attenuates the Upregulated Matrix Metalloprotease-2 Activity in a Rat Myocardial Infarction Model(Chronic coronary heart disease/Remodeling(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulatio
- PJ-564 Vasoconstrictor Effect of Aldosterone via Angiotensin II Type 1 Receptor in Mice Mesenteric Arterioles : Role of AT1 Receptor Dimerization(Cardiovascular pharmacology, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese Circulation
- PJ-465 Coupling Factor 6 Induces Coronary Arteriolar Vasoconstriction in Hypertensive Rats via Suppression of 8, 9-epoxyeicosatrienoic Acid (EET), 11, 12-EET, and 14, 15-EET(Coronary circulation, basic/clinical-4, The 71st Annual Scientific Meeting of the
- PJ-464 Vasoconstrictor Effect of Aldosterone in the Coronary Microcirculation is Enhanced in Hypertension Model but not in Diabetes Mellitus Model(Coronary circulation, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
- PJ-479 Coupling Factor 6 as a Novel Marker for the Development of Atherosclerosis(Atherosclerosis, clinical-11 (H) PJ81,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-008 Role of Angiotensin II Type-1 Receptor and Oxidative Stress in Aldosterone-induced Contraction of Rat Coronary Arterioles : Effect of Hypertension(Coronary circulation, basic/clinical-4 (IHD) PJ2,Poster Session (Japanese),The 70th Anniversary Annua
- Prognosis of the Patients with Acute Myocardial Infarction Presenting Two Vessel Occlusion : Comparison with Single Vessel Occlusion (Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 6 (IHD), The 69th Annual Scientific Meeting of the Japanese C
- Comparison of the Inhibitory Effects of Enalapril and Valsartan on Ventricular Remodeling in Patients with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 2 (IHD), The 69th Annual Scientific Meeting of the Japanese
- Beta-blocker Improves Prognostic Value after Acute Myocardial Infarction in Patients with Diabetes(Acute Myocardial Infarction, Clinical (Pathophysiology) 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model
- OJ-045 Pravastatin Attenuates Oxidative Stress in the Visceral Adipose Tissue and Increases Adiponectin Synthesis in Men With Coronary Artery Disease(Atherosclerosis, clinical(03)(IHD),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the
- PJ-562 Pravastatin Increases Circulating Adiponectin Level by Upregulating Gene Expression of Adiponectin in Visceral but not in Subcutaneous Adipose Tissue(Cardiovascular pharmacology, basic/clinical-6, The 71st Annual Scientific Meeting of the Japanese
- PJ-190 Pravastatin Decreases Plasma and Pericardial Levels of Matrix Metalloproteinase Activity by Reducing Oxidative Stress in Patients with Coronary Artery Disease(Angina pectoris, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Cir
- PJ-018 Granulocyte Colony-stimulating Factor in the Cardiac Interstitium is Increased in the Early Phase of Acute Myocardial Infarction(Acute myocardial infarction, clinical (pathophysiology)-4, The 71st Annual Scientific Meeting of the Japanese Circulati
- Increased Pericardial Fluid Level of Matrix Metalloproteinase-9 Activity in Patients With Acute Myocardial Infarction : Possible Role in the Development of Cardiac Rupture(Clinical Investigation)
- PJ-307 Pravastatin Decreases the Plasma and Pericardial Activities of Matrix Metalloproteinase via the Reduction of Oxidative Stress in Coronary Artery Disease(Angina pectoris, basic/clinical-4 (IHD) PJ52,Poster Session (Japanese),The 70th Anniversary Ann
- PE-469 Low Plasma Insulin-like Growth Factor-1 Level is Associated with Increased Cardiovascular Events in Low Risk Patients with Congestive Heart Failure(Heart failure, clinical-7 (M) PE79,Poster Session (English),The 70th Anniversary Annual Scientific M
- PE-124 Early Statin Treatment Prior to Coronary Intervention Attenuates Left Ventricular Remodeling in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-6 (IHD) PE21,Poster Session (English),The 70th Ann
- Coupling Factor 6 Induces Coronary Arteriolar Vasoconstriction in Hypertensive Rats via Suppression of Cytochrome P-450-derived Arachidonic Acid Metabolites(Coronary Circulation, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese C
- Role of Insulin-Like Growth Factor (IGF)-1 and IGF Binding Protein-3 in Left Ventricular Hypertrophy : Augmentation by Matrix Metalloproteinase (MMP)-2 Activity(Cardiac Hypertrophy 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Soci
- Upregulation of Matrix Metalloproteinase-9 by C-Reactive Protein in Rat Macrophages and Inhibitory Effect of Fluvastatin on It(Acute Coronary Syndrome, Basic/Clinical 6 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- X-Ray Rocking Curve Study of the Strain Profile Formed by MeV Ion Implantation into (111) Silicon Wafers
- Combination Therapy with an Angiotensin-Converting Enzyme (ACE) Inhibitor and a Calcium Antagonist: beyond the Renoprotective Effects of ACE Inhibitor Monotherapy in a Spontaneous Hypertensive Rat with Renal Ablation
- Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice
- OJ-186 Efficacy and Safety of Landiolol, an Ultra Short-acting, β 1-selective Adrenergic Blocker, in Patients with Acute Myocardial Infarction Undergoing PCI(OJ31,ACS/AMI (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific M
- OE-070 Plasma Soluble Lectin-like Oxidized Low-density Lipoprotein Receptor-1 Level at Admission can Predict In-hospital Prognosis in Patients with Acute Myocardial Infarction(OE12,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (English),The 7
- PJ-443 Inhibitory Effect of Low Dose Pioglitazone on the In-stent Restenosis in Patients with Acute Myocardial Infarction and Type 2 Diabetes(Acute myocardial infarction, clinical (diagnosis/treatment)-9 (IHD) PJ75,Poster Session (Japanese),The 70th Anniv
- Plasma Apelin Level Is Decreased in Patients with Coronary Artery Disease
- PJ-528 Pravastatin but not Rosuvastatin Increases the Adiponectin Level by Suppressing Oxidative Stress in the Visceral Adipose Tissue in CAD Patients(PJ089,Atherosclerosis (Clinical/Pathophysiology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scien
- PJ-041 Atorvastatin Attenuates C-reactive Protein-induced Increase in Coupling Factor 6, an Endogenous Inhibitor of Prostacyclin and Nitric Oxide, via Antioxidant Effect(Atherosclerosis, basic(05)(IHD),Poster Session(Japanese),The 72nd Annual Scientific M
- OE-283 Electrocardiographic characteristics in differentiating the mechanism and the origin of atrial tachycardia(ECG/Body surface potential mapping/Holter(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation So
- PJ-211 Amiodarone is Safe and Highly Effective Therapy for Supraventricular Tachycardia in Patient with Acute Heart Failure(Arrhythmia, therapy-18, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-159 Pravastatin Theraph Before Percutaneous Coronary Intervention Decreases the Circulating Osteopontin Level in Patients with Acute Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-7, The 71st Annual Scientific Meeting
- PJ-603 Enhanced Asymmetric Dimethylarginine Synthesis in the Atrium of a Canine Atrial Fibrillation Model : A Possible Role in Endocardial Remodeling(Arrhythmia, basic-5 (A) PJ101,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
- PJ-246 Pravastatin Increases Plasma and Pericardial Fluid Levels of Adiponectin in Patients with Ischemic Heart Disease(Lipid disorders-3 (H) PJ41,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society
- Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina
- PJ-436 Endogenous Brain Natriuretic Peptide Protects against Apoptosis of Ischemic Human Astrocytes in an Autocrine Fashion(PJ074,Cerebrovascular Circulation/Stroke (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
- FRS-063 Overexpression of Coupling Factor 6 Causes Cardiac Dysfunction under High Salt Intake in Mice(FRS13,Novel Molecular Mechanisms of Heart Failure 2 (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulatio
- Upregulation of Insulin-Like Growth Factor-1 Gene Expression in Cardiac Myocytes by Hypoxia : Mechanism for Its Cardioprotective Effect
- Generation and Characterization of Coupling Factor 6-Overexpressing Transgenic Mice
- PJ-916 Brain Natriuretic Peptide is Upregulated in Hypoxic Human Astrocytes via Activation of c-Src-signaling Pathway and Exerts Anti-apoptotic Effect(Neurohumoral factors(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- PJ-523 Salt-induced High Mortality in Mice Overexpressing Coupling Factor 6 : Involvement of Impaired Energy Supply and Calcium Handling in the Heart(Hypertension, basic(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Ci
- PJ-481 Linkage between tissue acidosis induced by coupling factor 6, an endogenous prostacyclin synthesis inhibitor, and type 2 diabetes in mice(Diabetes/Obesity/Metabolic syndrome(12)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the
- PJ-408 Coupling factor 6, an endogenous prostacyclin inhibitor, enhances soluble flt-1 release by acidosis-induced c-Src activation in vascular endothelial cells(Atherosclerosis, basic(07)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting o
- Lack of Association between Y Chromosome Alu Insertion Polymorphism and Hypertension
- Analysis of Aldehyde Dehydrogenase 2 Gene Polymorphism and Ethanol Patch Test as a Screening Method for Alcohol Sensitivity
- Angiotensin Converting Enzyme Gene Polymorphism and Its Enzyme Activity in Serum in Young Japanese Females
- OJ-062 Elevated Plasma Level of Asymmetrical Dimethylarginine in Patients with Atrial Fibrillation : Possible Role for Cardiovascular Events(Arrhythmia, diagnosis/pathophysiology/EPS-3 (A) OJ11,Oral Presentation (Japanese),The 70th Anniversary Annual Scie
- Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) : Digest Version
- PJ-327 Src-mediated hyperresponsiveness to angiotensin II in mice overexpressing coupling factor 6 in resistance arterioles(Hypertension, basic(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Trends in Antimicrobial Susceptibility of Streptococcus pneumoniae in the Tohoku District of Japan : A Longitudinal Analysis from 1998 to 2007
- PJ-028 p122 Protein, a Phospholipase C-δ1 Activator, is Upregulated by the Enhanced Gene Expression in Patients with Coronary Spastic Angina(Angina pectoris, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-757 The Effect of Vasoconstrictor Coupling Factor 6 on Nitric Oxide Production in Human Vascular Endothelial Cells(Endothelium-6 (H) PJ130,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-331 p122 Protein, a Positively Regulatory Protein for Phospholipase C (PLC) δ1, is Upregulated in Patients with Coronary Spastic Angina(Angina pectoris, basic/clinical-2 (IHD) OJ56,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Mee
- Effect of Vasoconstrictor Coupling Factor 6 on Gene Expression Profile in vascular Endothelial Cells : Involvement in Enhanced Asymmetric Dimethylarginine Release(Endothelium/NO 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society
- Angiotensin Converting Enzyme Inhibitor Enhances Efficacy of Amiodarone and not Class-I Antiarrhythmic Drug in Preventing Recurrence of Paroxysmal Atrial Fibrillation(Arrhythmia, Pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Jap
- Relationship between the Response to Antiarrhythmic Drug Therapy and the Development of Structural Remodeling in Patients with Paroxysmal Atrial Fibrillation(Arrhythmia, Diagnosis/Pathophysiology/EPS 3 (A), The 69th Annual Scientific Meeting of the Japane
- Efficacy of Antiarrhythmic Therapy in Preventing Recurrence of Paroxysmal Atrial Fibrillation not Showing Any Circadian Variation in the Onset(Arrhythmia, Pharmacological Therapy 1 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Societ
- Selective Carboxylation of Benzoic Acid Using Cyclodextrin as Mediator
- PJ-396 Brain Natriuretic Peptide is Upregulated in Hypoxic Human Astrocytes Via Activation of c-Src-signaling Pathway and Exerts Anti-apoptotic Effect(Neurohumoral factors-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-045 High-salt Intake Increases Mortality of Transgenic Mouse with Overexpression of Coupling Factor 6, an Endogenous Vasoconstrictor and Prostacyclin Synthesis Inhibitor(Hypertension, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulat
- Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation
- Lipocalin-Type PGD Synthase as a Novel Biomarker for Coronary Vasospasm
- Comparison of the effects of long-acting nifedipine CR and diltiazem R in patients with vasospastic angina : Aomori coronary spastic angina study
- 1 ICD Therapy may be Indicated in Selected, Asymptomatic Patients with Drug-Induced Type 1 Brugada ECG(Do patients with drug-induced Brugada type ECG have poor prognosis?,Controversy 6 (C-6) (A),Special Program,The 72nd Annual Scientific Meeting of the Ja
- Mutational Analysis of SLC12A3 Gene in a Japanese General Population of Northern Japan
- P-124 Laparotomy would be preferred over drainage for intestinal perforation in extremely low birth weight infants
- Survival of a congenital ileal atresia infant weighing 359g at birth after laparotomy
- Randomized Study on the Efficacy and Safety of Landiolol, an Ultra-Short-Acting β1-Adrenergic Blocker, in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
- Superantigenic Toxin Genes Coexist with Specific Staphylococcal Cassette Chromosome mec Genes in Methicillin-Resistant Staphylococcus aureus
- Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice
- Severe intraglomerular detachment of podocytes in a Gitelman syndrome patient
- Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy