＜Symposium V＞Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation

概要

論文の詳細を見る
Optimization of neuronal function and survival is an important goal in the treatment of cerebrovasculardiseases in order to avoid or improve devastating long-term sequelae. Nerve growth factor （NGF） is essential forneuronal growth and survival in the central nervous system （CNS）. Vascular endothelial growth factor （VEGF） isa potent mitogen specifi c for endothelial cells and a stimulator of neovascularization. VEGF also enhances vascularpermeability, which may promote the development of brain edema during cerebral ischemia. These molecules aff ectthe outcome of ischemia/reperfusion injury in the CNS. Edaravone, a brain-penetrant, free radical scavenger, isknown to ameliorate postischemic neuronal dysfunction. Transcription factor Nrf2（ nuclear factor-erythroid 2-relatedfactor 2）, a master regulator of antioxidant responses, plays an important role in the coordinated expressions ofstress-inducible genes. Astrocytes express various genes involved in the regulation of neuronal functions, and theregulation of astrocyte gene expressions may be a potential therapeutic target in brain injury. This review aims toappraise the eff ects of radical scavenger edaravone and a natural Nrf2-inducer as neuroprotective agents in humanastrocytes, particularly under an experimental model for hypoxia/reoxygenation.