The role of NEDD8 Ultimate Buster 1, NUB1, in neurodegenerative α-synucleinopathies
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概要
- 論文の詳細を見る
NEDD8 is developmentally down-regulated ubiquitin-like protein, which can conjugate covalently to theirtarget proteins. Recently, we identifi ed NUB1 as a NEDD8-interacting protein, which is composed of 601 amino acidresidues with a calculated molecular mass of 69.1 kDa. More recently, we showed that NUB1 is an interferon-inducedprotein and also recruits NEDD8 to the proteasome for degradation. Here, we performed a yeast two-hybrid screeningusing NUB1 as bait and isolated the cDNA of synphilin-1 from a human testis cDNA library. Synphilin-1 is a majorcomponent of inclusion bodies found in the brains of patients with α-synucleinopathies, including Parkinson’s disease.Our biochemical study showed that NUB1 directly interacts with synphilin-1 through its NEDD8-binding site. Inaddition, our immunohistochemical study showed that NUB1, as well as synphilin-1, accumulates in the inclusion bodiesfound in the brains of patients with α-synucleinopathies. These fi ndings imply that NUB1 plays a role in the formationof synphilin-1-positive inclusions.
- 弘前大学の論文
著者
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Mori Fumiaki
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Med
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Tanji Kunikazu
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Med
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Wakabayashi Koichi
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Med
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TAKAHASHI Hitoshi
Department of Pathology, Brain Research Institute, Niigata University
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Mori Fumiaki
弘前大学大学院医学研究科附属脳神経血管病態研究施設 脳神経内科学
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Mori Fumiaki
Department Of Neuropathology Hirosaki University Graduate School Of Medicine
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Tanaka H
Department Of Pediatrics Hirosaki University School Of Medicine
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Tanji Kunikazu
Department Of Neuropathology Hirosaki University Graduate School Of Medicine
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Tanaka Hiroshi
Department Of Pediatrics Hirosaki University School Of Medicine
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Mori Fumiaki
Department Of Cardiology Kanto Medical Center Ntt Ec
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Kamitani Tetsu
Center for molecular Chaperone, Medical College of Georgia, Augusta
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Kamitani Tetsu
Department of Cardiology, The University of Texas M. D. A. Anderson Cancer Center
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Kamitani Tetsu
Center For Molecular Chaperone Medical College Of Georgia Augusta
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Kamitani Tetsu
Department Of Cardiology The University Of Texas M. D. Anderson Cancer Center
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Takahashi Hitoshi
Department Of Emergency And Critical Care Kinki University School Of Medicine
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Wakabayashi Koichi
Department Of Neuropathology Hirosaki University Graduate School Of Medicine
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Takahashi Hitoshi
Department Of Agricultural Chemistry Faclty Of Horticulture Chiba University
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