Time Course of Free Radical Production After Primary Coronary Angioplasty for Acute Myocardial Infarction and the Effect of Vitamin C
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概要
- 論文の詳細を見る
Reactive oxygen species are thought to mediate reperfusion injury after rapid revascularization for acute myocardial infarction(AMI) and 8-epi prostaglandin(PG)F_<2α>, a free-radical catalyzed product of arachidonic acid, has been proposed as an indicator of oxidative stress in vivo during myocardial reperfusion. The time course of urinary 8-epi PGF_<2α> excretion after primary coronary angioplasty(PTCA) for AMI was investigated, as well as the effect of prior administration of vitamin C. Urine samples, 1 before and 5 after primary PTCA(0-30, 30-60, 60-90, 90-120 and 120-150 min), were collected in 11 patients with AMI undergoing primary PTCA(Group 1), 10 patients with AMI treated with water-soluble vitamin C at an initial dose of 2.0g followed by a constant infusion at 20 mg/min prior to primary PTCA(Group 2), and 6 patients with stable effort angina undergoing elective PTCA(Group 3). 8-epi PGF_<2α> was measured by enzyme immunoassay. There were no significant differences in urinary 8-epi PGF_<2α> excretion at baseline among the 3 groups. In Group 1, urinary 8-epi PGF_<2α> excretion(ng/mmol creatinine)significantly increased from 60±8 at baseline to 122±16 at 60-90 min(p<0.001), and declined to the baseline level at 120-150 min after primary PTCA. In Group 2, it also increased from 72±12 to 123±15 at 60-90 min(p<0.01), and the percent increase did not differ from that in Group 1. In Group 3, it remained unchanged during the study period. The free radical production is rapidly and transiently enhanced after primary PTCA for AMI, and vitamin C fails to suppress it.
- 社団法人日本循環器学会の論文
- 1999-11-20
著者
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Osanai Tomohiro
the Second Department of Internal Medicine, Hirosaki University School of medicine
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Okumura Ken
the Second Department of Internal Medicine, Hirosaki University School of medicine
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Okumura Ken
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Hanada Hiroyuki
The Second Department of Internal Medicine, Hirosaki University School of Medicine
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Ishizaka Hiroshi
The Second Department of Internal Medicine, Hirosaki University School of Medicine
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Guan Weiping
The Second Department of Internal Medicine, Hirosaki University School of Medicine
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Kamada Takaatsu
The Second Department of Internal Medicine, Hirosaki University School of Medicine
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Okumura Ken
The Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Kamada Takaatsu
Second Department of Internal Medicine, Hirosaki University School of Medicine
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Osanai Tomohiro
Department Of Cardiology Hirosaki University Graduate School Of Medicine Hirosaki Japan
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Guan Weiping
The Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Kamada Takaatsu
Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Ishizaka Hiroshi
Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of
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Ishizaka Hiroshi
The Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Okumura Ken
The Division Of Cardiology Hirosaki University Graduate School Of Medicine
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Okumura Ken
Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of
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