Efficacy of Amiodarone for Preventing the Recurrence of Symptomatic Paroxysmal and Persistent Atrial Fibrillation After Cardioversion
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概要
- 論文の詳細を見る
Background It has been previously reported that the efficacy of class I antiarrhythmics in preventing the recurrence of symptomatic paroxysmal and persistent atrial fibrillation (AF) is limited when AF lasts for 48h or more. However, it is unclear whether the efficacy of amiodarone, a class III drag, is superior to class I antiarrhythmics in patients with long-lasting AF. Method and Results The relationship between the duration of tachycardia and the efficacy of amiodarone in preventing recurrence of tachycardia was examined in 55 patients (37 men, 18 women, mean age 68±9 years) to whom amiodarone was administered after electrical or pharmacological cardioversion for paroxysmal and persistent AF. In 26 patients, paroxysmal and persistent AF ceased within 48h after onset (Group A), and in the other 29 patients, it ceased after 48h (Group B). Patient characteristics and actuarial recurrence-free rates were compared between the 2 groups. The mean follow-up period was 30±11 months. No statistically significant difference between the groups was found in patient characteristics. Actuarial recurrence-free rates in Group A and B at 1, 3, 6, 9, and 12 months were 100%, 81%, 69%, 62%, and 54%, and 93%, 79%, 66%, 52%, and 48%, respectively (p=NS at 12 months). The period of maintenance of sinus rhythm was 14.7±3.2 months in group A and 13.3±3.3 months in group B (mean±SE, p=NS). Conclusion In the case of amiodarone, efficacy for maintaining sinus rhythm after cardioversion of AF was not biased by the duration of arrhythmia. This observation suggests amiodarone is effective in maintaining normal sinus rhythm after cardioversion, even in patients with long-lasting AF and electrical atrial remodeling.
- 社団法人日本循環器学会の論文
- 2006-12-20
著者
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Sato Yoshihiro
Division Of Cardiology Department Of Internal Medicine And Memorial Heart Center Iwate Medical Unive
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Tachibana Hideaki
Division Of Cardiology Department Of Internal Medicine And Memorial Heart Center Iwate Medical Unive
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Komatsu Takashi
Division Of Cardiology Department Of Internal Medicine And Memorial Heart Center Iwate Medical Unive
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Nakamura M
Department Of Internal Medicine Division Of Cardiology And Memorial Heart Center Iwate Medical Unive
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Nakamura Motoyuki
Division Of Cardiology Department Of Internal Medicine And Memorial Heart Center Iwate Medical Unive
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Okumura Ken
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Okumura Ken
Second Department Of Internal Medicine Hirosaki University
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NAKAMURA Motoyuki
Second Department of Internal Medicine, School of Medicine, Iwate Medical University
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KOMATSU Takashi
Second Department of Internal Medicine, Iwate Medical University School of Medicine
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TACHIBANA Hideaki
Second Department of Internal Medicine, Iwate Medical University School of Medicine
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SATO Yoshihiro
Second Department of Internal Medicine, Iwate Medical University School of Medicine
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OZAWA Mahito
Second Department of Internal Medicine, Iwate Medical University School of Medicine
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Ozawa Mahito
Division Of Cardiology Department Of Internal Medicine And Memorial Heart Center Iwate Medical Unive
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Okumura Ken
Second Department Of Internal Medicine Hirosaki University School Of Medicine
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Nakamura M
Division Of Cardiology Department Of Internal Medicine And Memorial Heart Center Iwate Medical Unive
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Nakamura Motoyuki
Secon Department Of Internal Medicine Memorial Heart Center
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Okumura Ken
Department Of Cardiology Hirosaki University Hospital
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Koeda Tatsuhiko
Division Of Cardiology Department Of Internal Medicine And Memorial Heart Center Iwate Medical Unive
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Komatsu Takashi
Second Department Of Internal Medicine Iwate Medical University School Of Medicine
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