Plasma Apelin Level Is Decreased in Patients with Coronary Artery Disease
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概要
- 論文の詳細を見る
Adipose tissue secretes various bioactive molecules （adipokines）, and apelin is one kind of adipokines.Recently, it was shown that plasma apelin level is decreased in patients with chronic heart failure, and apelin mightplay an important role in the pathogenesis of cardiovascular disease. However, plasma apelin level in coronary arterydisease（ CAD） or other heart disease such as valvular heart disease（ VHD） has not been elucidated. We enrolled 31patients with CAD and 14 patients with VHD who underwent elective cardiac surgery. We also examined plasmaapelin level in 20 healthy subjects （Control）. Blood samples were obtained before the surgery. Paired samples ofvisceral and subcutaneous adipose tissues were harvested during surgery. Plasma apelin level was lower in both CADand VHD than in Control. When compared between CAD and VHD, it was lower in CAD than in VHD, and was notaff ected by treatment with HMG-CoA reductase inhibitors （statins） which was shown to increase adiponectin level.Left ventricular ejection fraction（ LVEF） was lower in CAD than in VHD. There was no correlation between plasmaapelin level and LVEF. Gene expression of apelin in visceral adipose tissue was higher than that in subcutaneousadipose tissue, but it was similar between two groups. These suggest that plasma apelin level was decreased inpatients with cardiac diseases, especially in those with CAD. Its role in the pathophysiology of CAD remains to beelucidated.
- 弘前大学の論文
著者
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Osanai Tomohiro
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of
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Okumura Ken
Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of
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Okumura Ken
心臓血管研究所
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Okumura Ken
Department Of Cardiology Respiratory Medicine And Nephrology Hirosaki University Graduate School Of
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Okumura Ken
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Sasaki Shingo
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Okumura Ken
Kumamoto University School Of Medicine Kumamoto Japan
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Saito Shin
Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University
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Fukuda Ikuo
Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine
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Daitoku Kazuyuki
Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine,
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Fukuda Ikuo
Department Of Cardiovascular Surgery Hirosaki University School Of Medicine
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YOKOYAMA Hiroaki
Department of Cardiology, Hirosaki University Graduate School of Medicine
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Okumura Ken
The First Department Of Internal Medicine Kumamoto University Medical School
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Higuma Takumi
Department of Cardiology, Hirosaki University School of Medicine
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Hanada Hiroyuki
Department of Cardiology, Hirosaki University School of Medicine
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Saito Shin
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Okumura Ken
Department Of Cardiology Hirosaki University Graduate School Of Medicine Hirosaki Japan
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Okumura Ken
Department Of Cardiology Hirosaki University School Of Medicine
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Osanai Tomohiro
Department Of Cardiology Hirosaki University Graduate School Of Medicine Hirosaki Japan
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Higuma Takumi
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Saitoh Shin
弘前大学 循環呼吸腎臓内科学
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Sagara Shigeki
Department Of Cardiology Hirosaki University Graduate School Of Medicine Hirosaki Japan
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Hanada Hiroyuki
Department Of Biology Faculty Of Science Kyushu University
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Daitoku Kazuyuki
Department Of Cardiovascular Surgery Hirosaki University School Of Medicine
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Daitoku Kazuyuki
Department Of Thoracic And Cardiovascular Surgery Hirosaki University Graduate School Of Medicine
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Daitoku Kazuyuki
Department Of Pharmacology Hirosaki University Graduate School Of Medicine
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Osanai Tomohiro
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Osanai Tomohiro
Department Of Cardiology Hirosaki University School Of Medicine
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Shibutani Shuji
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Yokoyama Hiroaki
Department Of Cardiology Hirosaki University Graduate School Of Medicine
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Yokoyama Hiroaki
Department Of Biochemical Engineering Faculty Of Pharmaceutical Sciences Osaka University
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Okumura Ken
The Division Of Cardiology Hirosaki University Graduate School Of Medicine
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Okumura Ken
Department Of Cardiology Hirosaki University Hospital
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Fukuda Ikuo
Department Of Thoracic And Cardiovascular Surgery Respiratory Medicine And Nephrology Hirosaki Unive
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横山 公章
Department of Cardiology, Hirosaki University Graduate School of Medicine
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齋藤 新
Department of Cardiology, Hirosaki University Graduate School of Medicine
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樋熊 拓未
Department of Cardiology, Hirosaki University Graduate School of Medicine
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Higuma Takumi
Department of Cardiology, Hirosaki University Graduate School of Medicine
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Hanada Hiroyuki
Department of Cardiology, Hirosaki University Graduate School of Medicine
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Okumura Ken
Department of Advance Management of Cardiac Arrhythmias Hirosaki University Graduate School of Medicine
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