Eplerenone Improved Hypokalemia in a Patient with Gitelman's Syndrome
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概要
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A 47-year-old woman presented with hypokalemia (2.4 mmol/L). She also had hypomagnesemia, hypocalciuria, and hyperreninemic hyperaldosteronism. Sequence analysis revealed a compound heterozygous mutation, R655C and R955Q, in the SLC12A3 gene. These findings were compatible with Gitelman's syndrome (GS). Eplerenone, a selective aldosterone blocker, in combination with oral potassium chloride improved serum potassium level (3.6 mmol/L) with no apparent adverse effect. Although eplerenone has an advantage over spironolactone for its selective affinity for the aldosterone receptor, the efficacy and safety of eplerenone for GS is little understood. Our observation suggests that eplerenone is a useful treatment option for GS.
著者
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Oiso Yutaka
Department Of Endocrinology And Diabetes Nagoya University Graduate School Of Medicine
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Tsutaya Shoji
Department Of Clinical Laboratory Hirosaki University Hospital
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Yoshida Masanori
Department Of Biotechnology Faculty Of Science And Engineering Ritsumeikan University
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ITO Yukiko
Department of Biopharmaceutics, Kyoto Pharmaceutical University
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Miyata Misaki
Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, Japan
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Nakayama Mikihiro
Nakayama Clinic, Japan
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Ogawa Koichiro
Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, Japan
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Maeda Harumi
Department of Endocrinology and Diabetes, Nagoya Ekisaikai Hospital, Japan
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