Effect of Pilsicainide on Atrial Electrophysiologic Properties in the Canine Rapid Atrial Stimulation Model : A Possible Suppressive Effect on Atrial Electrical Remodeling
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概要
- 論文の詳細を見る
The heterogeneous process of atrial electrical remodeling (AER) in the canine rapid atrial stimulation model has been previously reported although it has been reported that a sodium channel blocker might suppress the shortening of the atrial effective refractory period (AERP), its effect on long-term electrical remodeling is unknown. In the present study, the effect of pilsicainide on AER was evaluated. The right atrial appendage (RAA) was paced at 400 beats/min for 2 weeks. In the RAA, Bachmann's bundle (BB), the right atrium near the inferior vena cava (IVC) and in the left atrium (LA),AERP, AERP dispersion (AERPd) and the inducibility of atrial fibrillation (AF) were evaluated at several time points of the pacing phase and the recovery phase (1 week). The same protocol was performed during the administration of pilsicainidc (4.5mg/kg per day)and the parameters were comparede with the controls. Ln the control dogs,the AERP was significantly shortened by rapid pacing at all atrial sites studied and the AERP shortening (ΔAERP) was larger at the RAA and LA sites (p<0.03). However,pilsicainide decreased these ΔAERPs at all 4 atrial sites.AERPd was increased during the pacing phase whereas it was decreased during the recovery phase in the control dogs. In contrast, this pacing-induced AERPd was attenuated by the administration of pilsicainide. The AF inducibility was highest at the LA site in both groups, and the inducibility was lower in the pilsicainide group than the control group at all atrial sites. During the rapid pacing phase, the ventricular heart rate was significantly lower in the pilsicainide group than the control because of intra-atrial conduction block. In a canine rapid right atrial stimulation model, pilsicainide suppressed the shortening of the AERP at all atrial sites, possibly through the improvement of the hemodynamics as well as the action of the Na-Ca exchanger. (Circ J 2003 ; 67 : 340-346)
- 社団法人日本循環器学会の論文
- 2003-03-20
著者
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IZUMI Toru
Department of Neurology,Tsukazaki Memorial Hospital
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NIWANO Shinichi
Department of Cardio-Angiology, Kitasato University School of Medicine
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MORIGUCHI Masahiko
Department of Cardio-Angiology, Kitasato University School of Medicine
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Izumi Tohru
北里大学 医学部循環器内科
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Ikeda Kazuko
Department of Internal Medicine, Kitasato University School of Medicine
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SAITO Junko
Department of Obstetrics and Gynecology, Osaka University Medical School
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Kojima Jisho
Department of Cardio-angiology, Kitasato University School of Medicine
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Moriguchi Masahiko
北里大学 医学部循環器内科学
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Moriguchi Masahiko
Department Of Cardio-angiology Kitasato University School Of Medicine
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Moriguchi Masahiko
Department Of Internal Medicine/cardiology Kitasato University School Of Medicine
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Kojima Jisho
北里大学 医学部循環器内科学
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Kojima Jisho
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Shinichi
日本不整脈学会
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Inuo Kimiatsu
Department of internal Medicine,Kitasato University School of Medicine
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Ikeda Kazuko
Department Of Internal Medicine Kitasato University School Of Medicine
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Miwano Shinichi
北里大学
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Kojima Jisyo
Department Of Internal Medicine Kitasato University School Of Medicine
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Inuo Kimiatsu
北里大学 内科学
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Inuo Kimiatsu
Department Of Internal Medicine Kitasato University School Of Medicine
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Saitou Junko
Department Of Internal Medicine Kitasato University School Of Medicine
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Saito Junko
Department Of Biology Faculty Of Education Yamanashi University
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Niwano Shinichi
北里大学 医学部循環器内科学
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Izumi Toru
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University
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Ikeda Kazuko
Department Of Internal Medcine Kitasato University School Of Medicine
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Izumi Tohru
Department Of Internal Medicine And Cardiology And Gene Genetcs Kitasato University School Of Medici
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Kojima Jisho
Department Of Internal Medicine Kitasato University School Of Medicine
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NIWANO Shinichi
Department of Cardio-andiology, Kitasato University School of Medicine
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Niwano Shinichi
Department of Angio-Cardiology, Kitasato University School of Medicine
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IKEDA Kazuko
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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