Progression of Ventricular Remodeling and Arrhythmia in the Primary Hyperoxidative State of Glutathione-Depleted Rats
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概要
- 論文の詳細を見る
Background: Although oxidative stress is considered to promote arrhythmogenic substrates in diseased model animals, it is difficult to evaluate its primary role. In this study, we evaluated the promotion of arrhythmogenic substrates in the primary hyperoxidative state. Methods and Results: Sprague-Dawley rats were treated with L-buthionine-sulfoximine (BSO, 30mmol·L-1·day-1) for 14 days. On day 7 or 14, the serum levels of derivatives of reactive oxygen metabolites (d-ROM) were measured, and immune staining of 8-hydroxy-2-deoxyguanosine (8OHdG) was performed to assess oxidative stress. The ventricular effective refractory period (ERP), monophasic action potential duration (MAPD), and the inducibility of ventricular arrhythmia were also evaluated. BSO rats exhibited higher serum d-ROM and clearer 8OHdG staining than the controls. The inducibility of ventricular arrhythmia was higher in the BSO rats than in the controls. The ERP was shorter in the BSO rats than the control (day 14, 32±1 vs. 36±1ms, P<0.05), whereas the MAPD90 was longer in the BSO rats (day 14, 76±5 vs. 55±4ms, P<0.05). The mRNA levels of Kv4.2, erg, and SERCA2a were downregulated in the BSO rats (P<0.05), and Western blot analysis exhibited the downregulation of erg and SERCA2 expression in the BSO rats (P<0.05). Conclusions: Systemic oxidative stress might be one of the primary factors promoting cardiac electrophysiological remodeling and increasing the inducibility of arrhythmia independently of major organ disorders. (Circ J 2011; 75: 1386-1393)
- 2011-05-25
著者
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KUROKAWA Sayaka
Department of Cardio-Angiology, Kitasato University School of Medicine
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NIWANO Shinichi
Department of Cardio-Angiology, Kitasato University School of Medicine
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ISHIKAWA Shoko
Department of Cardio-Angiology, Kitasato University School of Medicine
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KOSUKEGAWA Tomoko
Department of Cardio-Angiology, Kitasato University School of Medicine
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Izumi Tohru
北里大学 医学部循環器内科
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Izumi Tohru
北里大学 医学部循環器内科学教室
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Izumi Tohru
北里大学
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Masaki Yoshihiko
Department of Cardio-angiology, Kitasato University School of Medicine
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Nakano Hironari
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Hiroe
北里大学 内科
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Niwano Hiroe
Department Of Cardio-angiology Kitasato University School Of Medicine
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Niwano Shinichi
日本不整脈学会
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Miwano Shinichi
北里大学
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Niwano Shinichi
Department Of Internal Medicine/cardiology Kitasato University School Of Medicine
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Niwano Hiroe
Department Of Internal Medcine Kitasato University School Of Medicine
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Izumi Tohru
北里大学 医学部循環器内科学
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Niwano Shinichi
北里大学 医学部循環器内科学
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Ishikawa Shoko
Department Of Cardio-angiology Kitasato University School Of Medicine
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Kurokawa Sayaka
Department Of Cardio-angiology Kitasato University School Of Medicine
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Masaki Yoshihiko
Department Of Cardio-angiology Kitasato University School Of Medicine
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Masaki Yoshihiko
Department Of Animal Laboratory Kitasato University School Of Medicine
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Kosukegawa Tomoko
Department Of Cardio-angiology Kitasato University School Of Medicine
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Izumi Tohru
Departments Of Cardio-angiology And Emergency And Critical Care Medicine Kitasato University School
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Kishihara Jun
Department Of Internal Medicine/cardiology Shizuoka City Shimizu Hospital
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Niwano Shinichi
Department Of Cardio-angiology Kitasato University
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Izumi Tohru
Department Of Cardio-angiology Kitasato University School Of Medcine
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Kishihara Jun
Department Of Cardio-angiology Kitasato University School Of Medicine
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Aoyama Yuya
Department Of Cardio-angiology Kitasato University School Of Medicine
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Izumi Tohru
Department Of Internal Medicine And Cardiology And Gene Genetcs Kitasato University School Of Medici
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Izumi Tohru
Department Of Angio-cardiology Kitasato University School Of Medicine
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NIWANO Shinichi
Department of Cardio-andiology, Kitasato University School of Medicine
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Niwano Shinichi
Department of Angio-Cardiology, Kitasato University School of Medicine
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